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dc.contributor.authorMorseth, Marianne S.
dc.contributor.authorHenjum, Sigrun
dc.contributor.authorSchwinger, Catherine
dc.contributor.authorStrand, Tor A
dc.contributor.authorShrestha, Sanjaya
dc.contributor.authorShrestha, Binob
dc.contributor.authorChandyo, Ram Krishna
dc.contributor.authorUlak, Manjeswori
dc.contributor.authorTorheim, Liv Elin
dc.date.accessioned2018-09-06T16:41:54Z
dc.date.accessioned2018-12-14T12:22:24Z
dc.date.available2018-09-06T16:41:54Z
dc.date.available2018-12-14T12:22:24Z
dc.date.issued2018-08-01
dc.identifier.citationMorseth M, Henjum S, Schwinger C, Strand TA, Shrestha S, Shrestha B, Chandyo RK, Ulak M, Torheim LE. Environmental Enteropathy, Micronutrient Adequacy and Length Velocity in Nepalese Children - the Mal-Ed Birth Cohort Study.. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 2018en
dc.identifier.issn0277-2116
dc.identifier.issn0277-2116
dc.identifier.issn1536-4801
dc.identifier.urihttps://hdl.handle.net/10642/6430
dc.description.abstractBackground: Nutrient deficiencies limit the growth and turnover of intestinal mucosa, but studies assessing whether specific nutrients protect against or improve environmental enteric dysfunction (EED) are scarce. We aimed to investigate associations between nutrient intake and EED assessed by lactulose:mannitol ratio, anti-1-antitrypsin, myeloperoxidase and neopterin among children 9-24 months in Bhaktapur, Nepal. Methods: Among 231 included children, nutrient intake was assessed monthly by 24 hour recalls, and 3-month usual intake was estimated using Multiple Source Method. Associations between nutrient intake and L:M ratio (measured at 15 months) were assessed using multiple linear regression, while associations between nutrient intake and fecal markers (measured quarterly) were assessed using Generalized Estimating Equations (GEE) models. Results: We found that associations between nutrient intake from complementary food and lactulose-mannitol (L:M) ratio, alpha-1-antitrypsin (AAT), myeloperoxidase (MPO) and neopterin (NEO) were generally negative but weak. The only significant associations between nutrient intake (Potassium, Magnesium, Phosphorous, Folate and Vitamin C) and markers for intestinal inflammation were found for MPO. Conclusion: Negative but weak associations between nutrient intake and markers of intestinal inflammation were found. Significant associations between several nutrients and MPO might merit further investigation.en
dc.description.sponsorshipThis work was supported by the Bill & Melinda Gates Foundation (grant number OPP47075); the Foundation for the NIH and the National Institutes of Health, Fogarty International Center.en
dc.language.isoenen
dc.publisherLippincott, Williams & Wilkinsen
dc.relation.ispartofseriesJournal of Pediatric Gastroenterology and Nutrition - JPGN;Volume 67 - Issue 2
dc.rightsThis is a non-final version of an article published in final form in Journal of Pediatric Gastroenterology and Nutrition - JPGNen
dc.subjectAnti-1-antitrypsinen
dc.subjectGeneralized estimating equation modelsen
dc.subjectMyeloperoxidaseen
dc.subjectNeopterinen
dc.subjectNutrient density adequaciesen
dc.titleEnvironmental Enteropathy, Micronutrient Adequacy and Length Velocity in Nepalese Children - the Mal-Ed Birth Cohort Studyen
dc.title.alternativeNutrient intake and environmental enteric dysfunction among Nepalese children 9-24 months old– the MAL-ED birth cohort studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2018-09-06T16:41:54Z
dc.description.versionacceptedVersionen
dc.identifier.doihttp://dx.doi.org/10.1097/MPG.0000000000001990
dc.identifier.cristin1578774
dc.source.journalJournal of Pediatric Gastroenterology and Nutrition - JPGN


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