Environmental Enteropathy, Micronutrient Adequacy and Length Velocity in Nepalese Children - the Mal-Ed Birth Cohort Study
Morseth, Marianne S.; Henjum, Sigrun; Schwinger, Catherine; Strand, Tor A; Shrestha, Sanjaya; Shrestha, Binob; Chandyo, Ram Krishna; Ulak, Manjeswori; Torheim, Liv Elin
Journal article, Peer reviewed
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https://hdl.handle.net/10642/6430Utgivelsesdato
2018-08-01Metadata
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Morseth M, Henjum S, Schwinger C, Strand TA, Shrestha S, Shrestha B, Chandyo RK, Ulak M, Torheim LE. Environmental Enteropathy, Micronutrient Adequacy and Length Velocity in Nepalese Children - the Mal-Ed Birth Cohort Study.. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 2018 http://dx.doi.org/10.1097/MPG.0000000000001990Sammendrag
Background: Nutrient deficiencies limit the growth and turnover of intestinal mucosa, but
studies assessing whether specific nutrients protect against or improve environmental enteric
dysfunction (EED) are scarce. We aimed to investigate associations between nutrient intake
and EED assessed by lactulose:mannitol ratio, anti-1-antitrypsin, myeloperoxidase and
neopterin among children 9-24 months in Bhaktapur, Nepal.
Methods: Among 231 included children, nutrient intake was assessed monthly by 24 hour
recalls, and 3-month usual intake was estimated using Multiple Source Method. Associations
between nutrient intake and L:M ratio (measured at 15 months) were assessed using multiple
linear regression, while associations between nutrient intake and fecal markers (measured
quarterly) were assessed using Generalized Estimating Equations (GEE) models.
Results: We found that associations between nutrient intake from complementary food and
lactulose-mannitol (L:M) ratio, alpha-1-antitrypsin (AAT), myeloperoxidase (MPO) and
neopterin (NEO) were generally negative but weak. The only significant associations between
nutrient intake (Potassium, Magnesium, Phosphorous, Folate and Vitamin C) and markers for
intestinal inflammation were found for MPO.
Conclusion: Negative but weak associations between nutrient intake and markers of intestinal
inflammation were found. Significant associations between several nutrients and MPO might
merit further investigation.