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Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited

dc.contributor.authorBrix, Maiken Kirkegaard
dc.contributor.authorErsland, Lars
dc.contributor.authorHugdahl, Kenneth
dc.contributor.authorGrüner, Renate
dc.contributor.authorPosserud, Maj-Britt Rocio
dc.contributor.authorHammar, Åsa
dc.contributor.authorCraig-Craven, Alexander Richard
dc.contributor.authorNoeske, Ralph
dc.contributor.authorEvans, C. John
dc.contributor.authorWalker, Hanne Bjørg Hansen
dc.contributor.authorMidtvedt, Tore
dc.contributor.authorBeyer, Mona K.
dc.date.accessioned2017-05-03T12:06:00Z
dc.date.accessioned2017-05-18T07:37:40Z
dc.date.available2017-05-03T12:06:00Z
dc.date.available2017-05-18T07:37:40Z
dc.date.issued2015
dc.identifier.citationBrix MK, Ersland L, Hugdahl K, Grüner R, Posserud M, Hammar Å, Craig-Craven A, Noeske, Evans, Walker HBH, Midtvedt T, Beyer MK. Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited. Frontiers in Human Neuroscience. 2015;9(365):1-12language
dc.identifier.issn1662-5161
dc.identifier.urihttps://hdl.handle.net/10642/4993
dc.description.abstractMagnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.language
dc.language.isoenlanguage
dc.publisherFrontiers Medialanguage
dc.rights© 2015 Brix, Ersland, Hugdahl, Grüner, Posserud, Hammar, Craven, Noeske, Evans, Walker, Midtvedt and Beyer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.language
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMRSlanguage
dc.subjectAutismlanguage
dc.subjectGABAlanguage
dc.titleBrain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisitedlanguage
dc.typeJournal articlelanguage
dc.typePeer reviewedlanguage
dc.date.updated2017-05-03T12:06:00Z
dc.description.versionpublishedVersionlanguage
dc.identifier.doihttp://doi.org/10.3389/fnhum.2015.00365
dc.identifier.cristin1256151
dc.relation.projectIDNorges forskningsråd: 223273


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© 2015 Brix, Ersland, Hugdahl, Grüner, Posserud, Hammar, Craven, Noeske, Evans, Walker, Midtvedt and Beyer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as © 2015 Brix, Ersland, Hugdahl, Grüner, Posserud, Hammar, Craven, Noeske, Evans, Walker, Midtvedt and Beyer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.