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dc.contributor.authorDomingo, Laia
dc.contributor.authorHofvind, Solveig
dc.contributor.authorHubbard, Rebecca A.
dc.contributor.authorRoman, Martha
dc.contributor.authorBenkeser, David
dc.contributor.authorSala, Maria
dc.contributor.authorCastells, Xavier
dc.date.accessioned2016-04-22T12:12:32Z
dc.date.available2016-04-22T12:12:32Z
dc.date.issued2015-11-11
dc.identifier.citationDomingo, L., Hofvind, S., Hubbard, R. A., Román, M., Benkeser, D., Sala, M., & Castells, X. (2015). Cross-national comparison of screening mammography accuracy measures in US, Norway, and Spain. European radiology, 1-9.en_US
dc.identifier.issn0938-7994
dc.identifier.issnFRIDAID 1307519
dc.identifier.urihttps://hdl.handle.net/10642/3286
dc.description.abstractObjective To compare accuracy measures for mammographic screening in Norway, Spain, and the US. Methods Information from women aged 50–69 years who underwent mammographic screening 1996–2009 in the US (898,418 women), Norway (527,464), and Spain (517,317) was included. Screen-detected cancer, interval cancer, and the false-positive rates, sensitivity, specificity, positive predictive value (PPV) for recalls (PPV-1), PPV for biopsies (PPV-2), 1/PPV-1 and 1/PPV-2 were computed for each country. Analyses were stratified by age, screening history, time since last screening, calendar year, and mammography modality. Results The rate of screen-detected cancers was 4.5, 5.5, and 4.0 per 1000 screening exams in the US, Norway, and Spain respectively. The highest sensitivity and lowest specificity were reported in the US (83.1 % and 91.3 %, respectively), followed by Spain (79.0 % and 96.2 %) and Norway (75.5 % and 97.1 %). In Norway, Spain and the US, PPV-1 was 16.4 %, 9.8 %, and 4.9 %, and PPV-2 was 39.4 %, 38.9 %, and 25.9 %, respectively. The number of women needed to recall to detect one cancer was 20.3, 6.1, and 10.2 in the US, Norway, and Spain, respectively. Conclusions Differences were found across countries, suggesting that opportunistic screening may translate into higher sensitivity at the cost of lower specificity and PPV. Key Points • Positive predictive value is higher in population-based screening programmes in Spain and Norway. • Opportunistic mammography screening in the US has lower positive predictive value. • Screening settings in the US translate into higher sensitivity and lower specificity. • The clinical burden may be higher for women screened opportunistically.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofseriesEuropean radiology;
dc.subjectMammographic screeningen_US
dc.subjectPositive predictive valueen_US
dc.subjectSensitivityen_US
dc.subjectSpecificityen_US
dc.subjectVariabilityen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Radiologi og bildediagnostikk: 763en_US
dc.titleCross-national comparison of screening mammography accuracy measures in U.S., Norway, and Spainen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00330-015-4074-8


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