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Recruitment challenges in clinical research including cancer patients and their caregivers. A randomized controlled trial study and lessons learned

Sygna, Karin; Johansen, Safora; Ruland, Cornelia
Journal article, Peer reviewed
© 2015 sygna et al. open access this article is distributed under the terms of the creative commons attribution 4.0 international license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the creative commons license, and indicate if changes were made. the creative commons public domain dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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URI
https://hdl.handle.net/10642/3067
Date
2015
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Original version
Sygna, K., Johansen, S. & Ruland, C. (2015). Recruitment challenges in clinical research including cancer patients and their caregivers. A randomized controlled trial study and lessons learned. Trials, 16(428). doi: 10.1186/s13063-015-0948-y   http://dx.doi.org/10.1186/s13063-015-0948-y
Abstract
Background: To test seven different strategies for recruitment in a randomized controlled trial, to report documented

response data from each strategy, and to discuss recruitment challenges.

Methods: We used 5 opt-in (potential participants have to do something active to contact or be contacted by the

researcher) and 2 opt-out (potential participants have the option to decline being contacted about a study) recruitment

strategies from February 2013 until July 2014 to contact 1562 cancer patient candidates for participation in a randomized

controlled trial. For each of these cancer patients a caregiver was also invited to take part in the study.

Results: Of the 1562 candidates, 22.6 % were ineligible on initial contact, 56.7 % declined to participate on initial

contact, and 8.9 % agreed orally to participate but did not complete the enrollment. The 2 opt-out strategies, on-site

recruitment and routine care letters recruitment, yielded the highest number of recruited participants with 79 dyads

and 58 dyads respectively, constituting 42.7 % and 31.4 % of the total number of enrolled candidates. The 5 opt-in

recruitment approaches yielded 49 dyads for the study. Almost half of these dyads were recruited using the approach

termed “relying on providers at the hospital.”

Conclusions: In this study, opt-out recruitment strategies appeared to be the most effective
Publisher
BioMed Central
Series
Trials;16(428)

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