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dc.contributor.authorBerstad, Paula Mariannaen_US
dc.contributor.authorThiis-Evensen, Espenen_US
dc.contributor.authorVatn, Morten H.en_US
dc.contributor.authorAlmendingen, Karien_US
dc.date.accessioned2013-10-10T11:30:51Z
dc.date.available2013-10-10T11:30:51Z
dc.date.issued2012en_US
dc.identifier.citationBerstad, P., Thiis-Evensen, E., Vatn, M. H., & Almendingen, K. (2012). Fatty Acids in Habitual Diet, Plasma Phospholipids, and Tumour and Normal Colonic Biopsies in Young Colorectal Cancer Patients. Journal of Oncology, 2012 (Article ID 254801).en_US
dc.identifier.issn1687-8450en_US
dc.identifier.otherFRIDAID: 979008en_US
dc.identifier.urihttps://hdl.handle.net/10642/1641
dc.description.abstractFatty acid metabolism is altered in colorectal cancer (CRC). We aimed to investigate incorporation of dietary n-6 and n-3 polyunsaturated fatty acids (PUFAs) into plasma phospholipids (PLs), tumour tissue, and normal mucosa in young CRC patients. We also aimed to study differences in PUFA composition between tumour and normal mucosa, and PUFA status associated with cancer stage. Sixty-five CRC patients younger than 55 years were included in a multicenter study. We assessed dietary fatty acid composition by food-frequency questionnaire. Fatty acid composition in plasma PL (n = 65) and tumour and normal colonic biopsies (n = 32) were analysed by gas chromatography. We observed a significant correlation for docosahexaenoic acid (DHA) between dietary intake and concentration in plasma PL (weight%) (r = 0.42; P = 0.001), but not for any n-6 PUFA. Tissue concentrations of arachidonic acid, eicosapentaenoic acid, and DHA (weight%) were 1.7–2.5 times higher in tumour than normal mucosa (P ≤ 0.001). Concentrations of n-3 and n-6 PUFA in plasma PL and tissues were not related to Duke’s stage, although patients with more severe cancer stage reported higher intake of n-3 PUFA. In conclusion, we found accumulation of the longchained n-3 and n-6 PUFA in tumour tissue in young CRC patientsen_US
dc.language.isoengen_US
dc.relation.ispartofseriesJournal of Oncology;Article ID 254801en_US
dc.subjectFettsyreren_US
dc.subjectKreft i tykktarm og endetarmen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectFatty acidsen_US
dc.subjectColorectal canceren_US
dc.titleFatty acids in habitual diet, plasma phospholipids, and tumour and normal colonic biopsies in young colorectal cancer patientsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionCopyright © 2012 Paula Berstad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.description.versionUtgivers pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1155/2012/254801


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