Fatty acids in habitual diet, plasma phospholipids, and tumour and normal colonic biopsies in young colorectal cancer patients
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Berstad, P., Thiis-Evensen, E., Vatn, M. H., & Almendingen, K. (2012). Fatty Acids in Habitual Diet, Plasma Phospholipids, and Tumour and Normal Colonic Biopsies in Young Colorectal Cancer Patients. Journal of Oncology, 2012 (Article ID 254801). http://dx.doi.org/10.1155/2012/254801Abstract
Fatty acid metabolism is altered in colorectal cancer (CRC). We aimed to investigate incorporation of dietary n-6 and n-3
polyunsaturated fatty acids (PUFAs) into plasma phospholipids (PLs), tumour tissue, and normal mucosa in young CRC patients.
We also aimed to study differences in PUFA composition between tumour and normal mucosa, and PUFA status associated with
cancer stage. Sixty-five CRC patients younger than 55 years were included in a multicenter study. We assessed dietary fatty acid
composition by food-frequency questionnaire. Fatty acid composition in plasma PL (n = 65) and tumour and normal colonic
biopsies (n = 32) were analysed by gas chromatography. We observed a significant correlation for docosahexaenoic acid (DHA)
between dietary intake and concentration in plasma PL (weight%) (r = 0.42; P = 0.001), but not for any n-6 PUFA. Tissue
concentrations of arachidonic acid, eicosapentaenoic acid, and DHA (weight%) were 1.7–2.5 times higher in tumour than normal
mucosa (P ≤ 0.001). Concentrations of n-3 and n-6 PUFA in plasma PL and tissues were not related to Duke’s stage, although
patients with more severe cancer stage reported higher intake of n-3 PUFA. In conclusion, we found accumulation of the longchained
n-3 and n-6 PUFA in tumour tissue in young CRC patients