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Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study

Jenum, Anne Karen; Mørkrid, Kjersti; Sletner, Line; Vangen, Siri; Torper, Johan; Nakstad, Britt; Voldner, Nanna; Rognerud-jensen, Odd H,; Stølevik, Sveinung Berntsen; Mosdøl, Annhild; Skrivarhaug, Torild; Vårdal, Mari H.; Holme, Ingar Morten K.; Yajnik, Chittaranjan S.; Birkeland, Kåre I.
Journal article, Peer reviewed
© 2012 european society of endocrinology this is an open access article distributed under the terms of the european journal of endocrinology's re-use licence which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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URI
https://hdl.handle.net/10642/1119
Date
2011
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  • HV - Institutt for rehabiliteringsvitenskap og helseteknologi [325]
Original version
Jenum, A.K., Mørkrid, K., Sletner, L., Vangen, S., Torper, J., Nakstad, B., Birkeland, K. (2011). Gestational diabetes with the WHO and modified International Association of Diabetes and Pregnancy Study Groups criteria: Impact of ethnicity. A population-based cohort study. European Journal of Endocrinology,   http://dx.doi.org/10.1530/EJE-11-0866
Abstract
Objective The International Association of Diabetes and Pregnancy Study Groups (IADPSG) recently proposed new criteria for diagnosing gestational diabetes mellitus (GDM). We compared prevalence rates, risk factors, and the effect of ethnicity using the World Health Organization (WHO) and modified IADPSG criteria.

Methods This was a population-based cohort study of 823 (74% of eligible) healthy pregnant women, of whom 59% were from ethnic minorities. Universal screening was performed at 28±2 weeks of gestation with the 75 g oral glucose tolerance test (OGTT). Venous plasma glucose (PG) was measured on site. GDM was diagnosed as per the definition of WHO criteria as fasting PG (FPG) ≥7.0 or 2-h PG ≥7.8 mmol/l; and as per the modified IADPSG criteria as FPG ≥5.1 or 2-h PG ≥8.5 mmol/l.

Results OGTT was performed in 759 women. Crude GDM prevalence was 13.0% with WHO (Western Europeans 11%, ethnic minorities 15%, P=0.14) and 31.5% with modified IADPSG criteria (Western Europeans 24%, ethnic minorities 37%, P< 0.001). Using the WHO criteria, ethnic minority origin was an independent predictor (South Asians, odds ratio (OR) 2.24 (95% confidence interval (CI) 1.26–3.97); Middle Easterners, OR 2.13 (1.12–4.08)) after adjustments for age, parity, and prepregnant body mass index (BMI). This increased OR was unapparent after further adjustments for body height (proxy for early life socioeconomic status), education and family history of diabetes. Using the modified IADPSG criteria, prepregnant BMI (1.09 (1.05–1.13)) and ethnic minority origin (South Asians, 2.54 (1.56–4.13)) were independent predictors, while education, body height and family history had little impact.

Conclusion GDM prevalence was overall 2.4-times higher with the modified IADPSG criteria compared with the WHO criteria. The new criteria identified many subjects with a relatively mild increase in FPG, strongly associated with South Asian origin and prepregnant overweight
Publisher
European Society of Endocrinology
Series
European Journal of Endocrinology;2011

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