Metabolic switching of human skeletal muscle cells in vitro
Journal article, Peer reviewed
N o t i c e: this is the author’s version of a work that was accepted for publication in prostaglandins leukotrienes and essential fatty acids. changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. changes may have been made to this work since it was submitted for publication. a definitive version was subsequently published in prostaglandins leukotrienes and essential fatty acids, 85 (5), 2011. http://dx.doi.org/10.1016/j.plefa.2011.04.017
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Original versionThoresen, H.G., Hessvik, N. P., Bakke, S. S., Aas, V. & Rustan, A. (2011). Metabolic switching of human skeletal muscle cells in vitro. Prostaglandins leukotrienes and essential fatty acids, 85 (5), 227-234. http://dx.doi.org/10.1016/j.plefa.2011.04.017
In this review we will focus on external factors that may modify energy metabolism in human skeletal muscle cells (myotubes) and the ability of the myotubes to switch between lipid and glucose oxidation. We describe the metabolic parameters suppressibility, adaptability and substrate-regulated flexibility, and show the influence of nutrients such as fatty acids and glucose (chronic hyperglycemia), and some pharmacological agents modifying nuclear receptors (PPAR and LXR), on these parameters in human myotubes. Possible cellular mechanisms for changes in these parameters will also be highlighted.