Browsing ODA Open Digital Archive by Author "Rein, Idun Dale"
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New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX.
Rein, Idun Dale; Stokke, Caroline; Jalal, Marwa; Myklebust, June H.; Patzke, Sebastian; Stokke, Trond (Cell Cycle;14(20), Journal article; Peer reviewed, 2015-08-28)Induction of DNA double strand breaks leads to phosphorylation and focus-formation of H2AX. However, foci of phosphorylated H2AX (γH2AX) appear during DNA replication also in the absence of exogenously applied injury. We ... -
Synthetic lethality by inhibition of PARP in ATM-deficient lymphoid cells : reduced proliferation, replication induced DNA damage, G2 delay and cell death
Rein, Idun Dale (Master thesis, 2012)Cells that are deficient in proteins involved in homologous recombination repair (HRR) have been shown to be hypersensitive to PARP inhibitors. While a cell may tolerate PARP inhibition or HRR defects alone, the combination ...