• Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 

      Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard (Journal article; Peer reviewed, 2017)
      Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like ...
    • The janus face of VEGF in stroke 

      Geiseler, Samuel; Morland, Cecilie (International Journal of Molecular Sciences;Volume 19, Issue 5, Journal article; Peer reviewed, 2018-05-04)
      The family of vascular endothelial growth factors (VEGFs) are known for their regulation ofvascularization. Inthebrain,VEGFsareimportantregulatorsofangiogenesis,neuroprotectionand neurogenesis. Dysregulation of VEGFs is ...
    • L‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA1 

      Lambertus, Marvin; Øverberg, Linda Thøring; Andersson, Krister Andreas; Hjelden, Malin Sørli; Hadzic, Alena; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Geiseler, Samuel; Morland, Cecilie (Acta Physiologica;Volume 231, Issue 3, Peer reviewed; Journal article, 2020-11-26)
      Aim: Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular-subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological ...