• Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 

      Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard (Journal article; Peer reviewed, 2017)
      Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like ...
    • Exercise-induced brain plasticity − potential roles of lactate receptor HCA1 in neurogenesis and mood regulation, and neurotrophic factors in stroke 

      Øverberg, Linda Thøring (OsloMet Avhandling;2023 nr 19, Doctoral thesis, 2023)
      The brain is highly plastic. It responds to changes in the environment by reorganizing pathways, creating new connections, or strengthening existing ones, rewiring itself, as well as by creating new blood vessel and neurons. ...
    • Identifying pain and distress in non-verbal persons with intellectual disability: Professional caregivers' and parents' attitudes towards using wearable sensors 

      Øderud, Tone; Boysen, Elin Sundby; Strisland, Frode; Dahl, Inger-Lise; Bull, Emilie Meyer; Hassel, Bjørnar; Morland, Cecilie (Peer reviewed; Journal article, 2023)
      BACKGROUND: Persons with severe intellectual disability (ID) may be non-verbal and unable to communicate pain or distress. Consequently, painful conditions may go undetected, and non-verbal persons with ID may not receive ...
    • The janus face of VEGF in stroke 

      Geiseler, Samuel; Morland, Cecilie (International Journal of Molecular Sciences;Volume 19, Issue 5, Journal article; Peer reviewed, 2018-05-04)
      The family of vascular endothelial growth factors (VEGFs) are known for their regulation ofvascularization. Inthebrain,VEGFsareimportantregulatorsofangiogenesis,neuroprotectionand neurogenesis. Dysregulation of VEGFs is ...
    • L‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA1 

      Lambertus, Marvin; Øverberg, Linda Thøring; Andersson, Krister Andreas; Hjelden, Malin Sørli; Hadzic, Alena; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Geiseler, Samuel; Morland, Cecilie (Acta Physiologica;Volume 231, Issue 3, Peer reviewed; Journal article, 2020-11-26)
      Aim: Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular-subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological ...
    • Plasma levels of BDNF and EGF are reduced in acute stroke patients 

      Øverberg, Linda Thøring; Lugg, Elise Fritsch; Gaarder, Mona; Langhammer, Birgitta; Thommessen, Bente; Rønning, Ole Morten; Morland, Cecilie (Heliyon;Volume 8, Issue 6, e09661, Peer reviewed; Journal article, 2022-06-17)
      Stroke affects almost 14 million people worldwide each year. It is the second leading cause of death and a major cause of acquired disability. The degree of initial impairment in cognitive and motor functions greatly affects ...