Blar i ODA Open Digital Archive på forfatter "Grotmol, Tom"

Viser treff 1-7 av 7

    • Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome 

      Bucher-Johannessen, Cecilie; Page, Christian Magnus; Haugen, Trine B.; Wojewodzic, Marcin; Fosså, Sophie Dorothea; Grotmol, Tom; Haugnes, Hege Sagstuen; Rounge, Trine Ballestad (Clinical Epigenetics;11, Article number: 179 (2019), Journal article; Peer reviewed, 2019-12-03)
      Background: Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. In this epigenomewide ...

    • Gene variations in sex hormone pathways and the risk of testicular germ cell tumour: a case–parent triad study in a Norwegian–Swedish population 

      Kristiansen, Wenche; Andreassen, Kristine Engen; Karlsson, Robert; Aschim, Elin Leirvoll; Bremnes, Roy M.; Dahl, Olav; Fosså, Sophie Dorothea; Klepp, Olbjørn; Langberg, Carl W.; Solberg, Arne; Tretli, Steinar; Adami, Hans-Olov; Wiklund, Fredrik; Grotmol, Tom; Haugen, Trine Berit (Human Reproduction;27 (5), Journal article; Peer reviewed, 2012-03-08)
      BACKGROUND Testicular germ cell tumour (TGCT) is the most common cancer in young men, and an imbalance between the estrogen and androgen levels in utero is hypothesized to influence TGCT risk. Thus, polymorphisms in genes ...

    • Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor 

      Litchfield, Kevin; Levy, Max; Orlando, Giulia; Loveday, Chey; Law, Philip J.; Migliorini, Gabriele; Holroyd, Amy; Broderick, Peter; Karlsson, Robert; Haugen, Trine B.; Kristiansen, Wenche; Nsengimana, Jérémie; Fenwick, Kerry; Assiotis, Ioannis; Kote-Jarai, Zsofia; Dunning, Alison M.; Muir, Kenneth; Peto, Julian; Eeles, Rosalind; Easton, Douglas F.; Dudakia, Darshna; Orr, Nick; Pashayan, Nora; Bishop, D. Timothy; Reid, Alison; Huddart, Robert A.; Shipley, Janet; Grotmol, Tom; Wiklund, Fredrik; Houlston, Richard S.; Turnbull, Clare (Nature Genetics;Volume 49, Issue 7, Journal article; Peer reviewed, 2017-06-12)
      Genome-wide association studies (GWAS) have transformed our understanding of testicular germ cell tumour (TGCT) susceptibility but much of the heritability remains unexplained. Here we report a new GWAS, a meta-analysis ...

    • Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor 

      Wang, Zhaoming; McGlynn, Katherine A.; Rajpert-De Meyts, Ewa; Bishop, D. Timothy; Chung, Charles C.; Dalgaard, Marlene D.; Greene, Mark H.; Gupta, Ramneek; Grotmol, Tom; Haugen, Trine B.; Karlsson, Robert; Litchfield, Kevin; Mitra, Nandita; Nielsen, Kasper; Pyle, Louise C.; Schwartz, Stephen M.; Thorsson, Vesteinn; Vardhanabhuti, Saran; Wiklund, Fredrik; Turnbull, Clare; Chanock, Stephen J.; Kanetsky, Peter A.; Nathanson, Katherine L. (Nature Genetics;Volume 49, Issue 7, Journal article; Peer reviewed, 2017-06-12)
      The international TEsticular CAncer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumors (TGCT; 3,558 cases and 13,970 controls) to identify novel susceptibility loci. ...

    • Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users 

      Ellingjord-Dale, Merete; Lee, Eunjung; Couto, Elisabeth; Ozhand, Ali; Qureshi, Samera A; Hofvind, Solveig; van Den Berg, David J; Akslen, Lars A; Grotmol, Tom; Ursin, Giske (Breast Cancer Research;14 (R135), Journal article; Peer reviewed, 2012-10-27)
      Introduction Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by ...

    • Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs 

      Rounge, Trine Ballestad; Furu, Kari; Skotheim, Rolf Inge; Haugen, Trine B.; Grotmol, Tom; Enerly, Espen (Journal article; Peer reviewed, 2015)
      Background Small non-coding RNAs play essential roles in gene regulation, however, the interplay between RNA groups, their expression levels and deregulations in tumorigenesis requires additional exploration. In particular, ...

    • Serum RNA profiling in the 10-year period prior to diagnosis of testicular germ cell tumour 

      Burton, Joshua; Umu, Sinan Uğur; Langseth, Hilde; Grotmol, Tom; Grimsrud, Tom Kristian; Haugen, Trine B.; Rounge, Trine Ballestad (Frontiers in Oncology;volume 10, Peer reviewed; Journal article, 2020-10-28)
      Although testicular germ cell tumor (TGCT) overall is highly curable, patients may experience late effects after treatment. An increased understanding of the mechanisms behind the development of TGCT may pave the way for ...