dc.contributor.author | Fang, Evandro Fei | |
dc.contributor.author | Lautrup, Sofie | |
dc.contributor.author | Hou, Yujun | |
dc.contributor.author | Demarest, Tyler G | |
dc.contributor.author | Croteau, Deborah L | |
dc.contributor.author | Mattson, Mark P | |
dc.contributor.author | Bohr, Vilhelm A | |
dc.date.accessioned | 2019-11-05T14:33:42Z | |
dc.date.available | 2019-11-05T14:33:42Z | |
dc.date.issued | 2017-10 | |
dc.identifier.citation | Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017). NAD+ in aging: molecular mechanisms and translational implications. Trends in molecular medicine, 23(10), 899-916. | en |
dc.identifier.issn | 1471-4914 | |
dc.identifier.uri | https://hdl.handle.net/10642/7796 | |
dc.description.abstract | AB The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD+ levels is important for cells with high energy demands and for proficient neuronal function. NAD+ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atrophy. Emerging evidence suggests that NAD+ decrements occur in various tissues during aging, and that physiological and pharmacological interventions bolstering cellular NAD+ levels might retard aspects of aging and forestall some age-related diseases. Here, we discuss aspects of NAD+ biosynthesis, together with putative mechanisms of NAD+ action against aging, including recent preclinical and clinical trials. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.ispartofseries | Trends in Molecular Medicine;23/10 | |
dc.rights | On non-commercial hosting platforms including institutional repository
Published source must be acknowledged
Must link to journal homepage with DOI
Publisher's version/PDF cannot be used
Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License | en |
dc.subject | NAD+; metabolism; autophagy; neurodegenerative disorder; mitophagy; aging; stem cell; DNA repair; clinical application | en |
dc.title | NAD+ in aging: molecular mechanisms and translational implications | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.description.version | submittedVersion | en |
dc.identifier.doi | http://dx.doi.org/10.1016/j.molmed.2017.08.001 | |