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dc.contributor.authorCatalano, Enrico
dc.contributor.authorBenedetto, Andrea Di
dc.date.accessioned2019-07-12T07:37:02Z
dc.date.available2019-07-12T07:37:02Z
dc.date.issued2017-05
dc.identifier.citationCatalano, E., & Di Benedetto, A. (2017, May). Characterization of physicochemical and colloidal properties of hydrogel chitosan-coated iron-oxide nanoparticles for cancer therapy. In Journal of Physics: Conference Series (Vol. 841, No. 1, p. 012010). IOP Publishing.en
dc.identifier.issn1742-6588
dc.identifier.urihttps://hdl.handle.net/10642/7276
dc.description.abstractSuperparamagnetic iron oxide nanoparticles have recently been investigated for their potential to kill cancer cells with promising results, owing to their ability to be targeted and heated by magnetic fields. In this study, novel hydrogel, chitosan Fe3O4 magnetic nanoparticles were synthesized to induce magnetic hyperthermia, and targeted delivering of chemotherapeutics in the cancer microenvironment. The characteristic properties of synthesized bare and CS-MNPs were analyzed by various analytical methods: X-ray diffraction, Fourier transformed infrared spectroscopy, Scanning electron microscopy and Thermo-gravimetric analysis/differential thermal analysis. Magnetic nanoparticles were successfully synthesized using the co-precipitation method. This synthesis technique resulted in nanoparticles with an average particle size of 16 nm. The pure obtained nanoparticles were then successfully encapsulated with 4-nm-thick chitosan coating. The formation of chitosan on the surface of nanoparticles was confirmed by physicochemical analyses. Heating experiments at safe magnetic field (f = 100 kHz, H =10-20 kA m-1) revealed that the maximum achieved temperature of water stable chitosan-coated nanoparticles (50 mg ml-1) is fully in agreement with cancer therapy and biomedical applications.en
dc.language.isoenen
dc.publisherIOP Publishingen
dc.relation.ispartofseriesJournal of Physics: Conference Series;841
dc.rightsAttribution 3.0 United States This is an open access article, originally published at https://doi.org/10.1088/1742-6596/841/1/012010en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectArtikkelen
dc.titleCharacterization of physicochemical and colloidal properties of hydrogel chitosan-coated iron-oxide nanoparticles for cancer therapyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionpublishedVersionen
dc.identifier.doihttps://doi.org/10.1088/1742-6596/841/1/012010
dc.identifier.cristin1493591


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Attribution 3.0 United States
This is an open access article, originally published at https://doi.org/10.1088/1742-6596/841/1/012010
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution 3.0 United States This is an open access article, originally published at https://doi.org/10.1088/1742-6596/841/1/012010