Vis enkel innførsel

dc.contributor.authorKristensen, Vendel Ailin
dc.contributor.authorSmåstuen, Milada Cvancarova
dc.contributor.authorHøivik, Marte Lie
dc.contributor.authorMoum, Bjørn
dc.contributor.authorVatn, Morten H
dc.date.accessioned2020-09-03T14:52:00Z
dc.date.accessioned2020-10-20T11:16:58Z
dc.date.available2020-09-03T14:52:00Z
dc.date.available2020-10-20T11:16:58Z
dc.date.issued2020-04-06
dc.identifier.citationKristensen VA, Småstuen MC, Høivik ML, Moum B, Vatn MH. Serological antibodies and surgery in a population-based inception cohort of Crohn's disease patients - the IBSEN study. Scandinavian Journal of Gastroenterology. 2020en
dc.identifier.issn0036-5521
dc.identifier.issn0036-5521
dc.identifier.issn1502-7708
dc.identifier.urihttps://hdl.handle.net/10642/9079
dc.description.abstractIntroduction: Serological antibodies have been associated with complicated disease course in Crohn’s disease (CD), including the need for surgery. Aim: The aim of this study was to investigate if a panel of relevant antibodies could predict surgery in a prospective population-based cohort of patients with CD. Methods: The population-based IBSEN cohort has been followed prospectively for 20years. At the 10and 20-year follow-up, the following panel of serological antibodies was analysed: pANCA, ASCA IgA, ASCA IgG, anti-OmpC, anti-I2, and anti-CBir1. At the 20-year follow-up or until lost to follow-up, all CDrelated surgeries were registered. Results: Serum was available from 159 patients at 10-year follow-up and 135 patients at 20-year follow-up. In 113 patients, serum was available at both time points. No significant change of antibody status (positive vs. negative) was found from 10-year to 20-year follow-up. Negative pANCA, positive ASCA IgA and positive ASCA IgG at 10-year follow-up were all individually associated with increased risk for CD-related surgery. There was no association between anti-OmpC, anti-I2 or anti-CBir1 and CDrelated surgery. In a multiple regression model including disease location and behaviour, only stricturing or penetrating disease behaviour and negative pANCA remained significantly associated with higher odds for surgery. Conclusion: Positive ASCA IgA and IgG, and negative pANCA were associated with higher odds for CD-related surgery in univariate analysis. Since disease phenotype changes during the disease course, while serological antibodies are stable, our results support the use of pANCA, ASCA IgA and ASCA IgG as prognostic markers in CD.en
dc.description.sponsorshipVAK has received a postdoctoral grant from the South Eastern Health Region of Norway.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.ispartofseriesScandinavian Journal of Gastroenterology;Volume 55, 2020 - Issue 4
dc.subjectBiomarkersen
dc.subjectCrohn’s diseaseen
dc.subjectEpidemiologyen
dc.subjectInflammatory bowel diseasesen
dc.subjectSerological antibodiesen
dc.subjectSurgeriesen
dc.titleSerological antibodies and surgery in a population-based inception cohort of Crohn's disease patients - the IBSEN studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2020-09-03T14:52:00Z
dc.description.versionpublishedVersionen
dc.identifier.doihttps://dx.doi.org/10.1080/00365521.2020.1745879
dc.identifier.cristin1808379
dc.source.journalScandinavian Journal of Gastroenterology


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel