Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health
dc.contributor.author | Svendsen, Karianne | |
dc.contributor.author | Olsen, Thomas | |
dc.contributor.author | Rusvik, Tove C. N. | |
dc.contributor.author | Ulven, Stine Marie | |
dc.contributor.author | Holven, Kirsten Bjørklund | |
dc.contributor.author | Retterstøl, Kjetil | |
dc.contributor.author | Telle-Hansen, Vibeke | |
dc.date.accessioned | 2020-05-21T15:04:13Z | |
dc.date.accessioned | 2020-05-28T10:11:41Z | |
dc.date.available | 2020-05-21T15:04:13Z | |
dc.date.available | 2020-05-28T10:11:41Z | |
dc.date.issued | 2020-05-21 | |
dc.identifier.citation | Svendsen, Olsen, Rusvik, Ulven, Holven, Retterstøl, Telle-Hansen. Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health. Lipids in Health and Disease. 2020 | en |
dc.identifier.issn | 1476-511X | |
dc.identifier.issn | 1476-511X | |
dc.identifier.uri | https://hdl.handle.net/10642/8657 | |
dc.description.abstract | Background: The aim was to investigate if fatty acid profile and estimated desaturase activities; stearoyl CoAdesaturase (SCD), delta-5-desaturase and delta-6-desaturase (D5D; D6D), differ between individuals with metabolically healthy (MH) and unhealthy (MU) phenotypes. We also explored these associations according to BMI categories. Methods: Men and women at moderately elevated risk of cardiovascular disease were included in this crosssectional study (n=321). If subjects met ≥4 out of 5 criteria (elevated triglycerides, total and LDL-cholesterol, HbA1c and low HDL-cholesterol), they were classified as MU (n=52). If levels were within reference ranges for ≥3 of the same criteria, subjects were classified as MH (n=150). Utilizing the entire population, a score ranging from 0 to 5 denoting the number of MU criteria met was computed. Estimated desaturase activities were calculated as productto-precursor ratio of fatty acids in whole blood (SCD16 [16:1n7/16:0], SCD18 [18:1n9/18:0], D5D [18:3n6/18:2n6], D6D [20:4n6/20:3n6]). Results: Individuals with MH had lower estimated SCD16 and SCD18 activities, whereas estimated D6D activity was higher compared to MU. Similar, SCD16 and SCD18 increased, whereas D6D decreased with increasing criteria of MU. Trends were similar across BMI categories. Conclusions: This study supports the notion of estimated desaturase activities as possible novel biomarkers of metabolic health irrespectively of BMI. | en |
dc.description.sponsorship | We received funding from Wendel Jarlsbergs (distributed by the non-profit organization UNIFOR) for analysis of fatty acids and development of the VISA-FFQ questionnaire used to report diet and physical activity. We also previously received funding from Vita hjertego’ (Mills DA) for work with the VISA-FFQ. | en |
dc.language.iso | en | en |
dc.publisher | BMC (part of Springer Nature) | en |
dc.relation.ispartofseries | Lipids in Health and Disease;19, Article number: 102 (2020) | |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Fatty acids | en |
dc.subject | Desaturases | en |
dc.subject | Obesity | en |
dc.subject | Metabolic diseases | en |
dc.subject | Stearoyl CoA desaturases | en |
dc.title | Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2020-05-21T15:04:13Z | |
dc.description.version | publishedVersion | en |
dc.identifier.doi | https://dx.doi.org/10.1186/s12944-020-01282-y | |
dc.identifier.cristin | 1812066 | |
dc.source.journal | Lipids in Health and Disease |
Tilhørende fil(er)
Denne innførselen finnes i følgende samling(er)
-
HV - Institutt for sykepleie og helsefremmende arbeid [1386]
HV - Department of Nursing and Health Promotion
Med mindre annet er angitt, så er denne innførselen lisensiert som This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.