A comprehensive metabolic profiling of the metabolically healthy obesity phenotype
dc.contributor.author | Telle-Hansen, Vibeke | |
dc.contributor.author | Christensen, Jacob J. | |
dc.contributor.author | Formo, Gulla | |
dc.contributor.author | Holven, Kirsten Bjørklund | |
dc.contributor.author | Ulven, Stine Marie | |
dc.date.accessioned | 2020-05-13T21:52:48Z | |
dc.date.accessioned | 2020-05-18T09:13:25Z | |
dc.date.available | 2020-05-13T21:52:48Z | |
dc.date.available | 2020-05-18T09:13:25Z | |
dc.date.issued | 2020-05-09 | |
dc.identifier.citation | Telle-Hansen VH, Christensen JJ, Formo, Holven KB, Ulven S. A comprehensive metabolic profiling of the metabolically healthy obesity phenotype. Lipids in Health and Disease. 2020;19:1-12 | en |
dc.identifier.issn | 1476-511X | |
dc.identifier.issn | 1476-511X | |
dc.identifier.uri | https://hdl.handle.net/10642/8614 | |
dc.description.abstract | Background: The ever-increasing prevalence of obesity constitutes a major health problem worldwide. A subgroup of obese individuals has been described as “metabolically healthy obese” (MHO). In contrast to metabolically unhealthy obese (MUO), the MHO phenotype has a favorable risk profile. Despite this, the MHO phenotype is still sub-optimally characterized with respect to a comprehensive risk assessment. Our aim was to increase the understanding of metabolic alterations associated with healthy and unhealthy obesity. Methods: In this cross-sectional study, men and women (18–70years) with obesity (body mass index (BMI)≥30kg/ m2) or normal weight (NW) (BMI≤25kg/m2) were classified with MHO (n=9), MUO (n=10) or NW (n=11) according to weight, lipid profile and glycemic regulation. We characterized individuals by comprehensive metabolic profiling using a commercial available high-throughput proton NMR metabolomics platform. Plasma fatty acid profile, including short chain fatty acids, was measured using gas chromatography. Results: The concentrations of very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and low density lipoprotein (LDL) subclasses were overall significantly higher, and high density lipoprotein (HDL) subclasses lower in MUO compared with MHO. VLDL and IDL subclasses were significantly lower and HDL subclasses were higher in NW compared with MHO. The concentration of isoleucine, leucine and valine was significantly higher in MUO compared with MHO, and the concentration phenylalanine was lower in NW subjects compared with MHO. The fatty acid profile in MHO was overall more favorable compared with MUO. Conclusions: Comprehensive metabolic profiling supports that MHO subjects have intermediate-stage cardiovascular disease risk marker profile compared with NW and MUO subjects. Clinical trial registration number: NCT01034436, Fatty acid quality and overweight (FO-study). | en |
dc.description.sponsorship | Throne Holst Foundation for Nutrition Research, Oslo, Norway, University of Oslo, Oslo, Norway, OsloMet, Oslo, Norway, and Mills DA, Oslo, Norway. | en |
dc.language.iso | en | en |
dc.publisher | BMC (part of Springer Nature) | en |
dc.relation.ispartofseries | Lipids in Health and Disease;19, Article number: 90 (2020) | |
dc.rights | © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Metabolically healthy obesity | en |
dc.subject | Metabolically unhealthy obesity | en |
dc.subject | Fatty acids | en |
dc.subject | Obeses | en |
dc.subject | Diets | en |
dc.subject | Glycemic regulations | en |
dc.title | A comprehensive metabolic profiling of the metabolically healthy obesity phenotype | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2020-05-13T21:52:48Z | |
dc.description.version | publishedVersion | en |
dc.identifier.doi | https://dx.doi.org/10.1186/s12944-020-01273-z | |
dc.identifier.cristin | 1810892 | |
dc.source.journal | Lipids in Health and Disease |
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HV - Institutt for sykepleie og helsefremmende arbeid [1425]
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Med mindre annet er angitt, så er denne innførselen lisensiert som © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.