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dc.contributor.authorAakre, Inger
dc.contributor.authorStrand, Tor A
dc.contributor.authorMoubarek, Khalil
dc.contributor.authorBarikmo, Ingrid
dc.contributor.authorHenjum, Sigrun
dc.date.accessioned2019-09-04T11:07:35Z
dc.date.accessioned2020-02-24T11:42:32Z
dc.date.available2019-09-04T11:07:35Z
dc.date.available2020-02-24T11:42:32Z
dc.date.issued2017-11-22
dc.identifier.citationAakre I, Strand TA, Moubarek, Barikmo I, Henjum S. Associations between thyroid dysfunction and developmental status in children with excessive iodine status. PLoS ONE. 2017;12(11)en
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10642/8161
dc.description.abstractBackground and objective: Adequate iodine status and normal thyroid hormone synthesis are important for optimal child development. In this study, we explored whether young children’s developmental status is associated with thyroid dysfunction in an area of chronic excessive iodine exposure. Methods: We included 298 children between 18 and 48 months of age residing in Algerian refugee camps. Early child development was measured using the Ages and Stages Questionnaires, third edition (ASQ-3), consisting of five domains: Communication, Gross Motor, Fine Motor, Problem Solving and Personal-Social. Due to poor discriminatory ability in the Gross Motor domain, the total ASQ-3 scores were calculated both including and excluding this domain. Urinary iodine concentration (UIC), thyroid hormones (TSH, FT3 and FT4), thyroid antibodies and serum thyroglobulin (Tg) were measured. Results: The median UIC was 451.6μg/L, and approximately 72% of the children had a UIC above 300μg/L. Furthermore, 14% had thyroid disturbances, of whom 10% had TSH outside the reference range. Children with thyroid disturbances and TSH outside the reference ranges had lower odds of being among the 66% highest total ASQ scores, with adjusted odds ratios (95% CI) of 0.46 (0.23, 0.93) and 0.42 (0.19, 0.94), respectively. Conclusion: We found an association between thyroid dysfunction and poorer developmental status among children with excessive iodine intake. The high iodine intake may have caused the thyroid dysfunction and hence the delayed developmental status; however, other influential factors cannot be excluded. Optimal child development is important for a sustainable future. With iodine excess being an increasing problem globally, this subject should be further explored.en
dc.description.sponsorshipThe study was funded by Oslo and Akershus University College (http://www.hioa.no/) to IA and The NorwegianChurch Aid (https://www. kirkensnodhjelp.no/) to IA. The fundingdid not include grant numbers.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofseriesPLoS ONE;12 (11): e0187241
dc.rights© 2017 Aakre et al. This is an open access article distributedunder the terms of the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproductionin any medium,provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectThyroidsen
dc.subjectIodineen
dc.subjectThyroid hormonesen
dc.subjectThyroid-stimulating hormonesen
dc.subjectChild developmentsen
dc.subjectMicronutrient deficienciesen
dc.titleAssociations between thyroid dysfunction and developmental status in children with excessive iodine statusen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2019-09-04T11:07:35Z
dc.description.versionpublishedVersionen
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0187241
dc.identifier.cristin1510264
dc.source.journalPLoS ONE


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© 2017 Aakre et al. This is an open access article distributedunder the terms of the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproductionin any medium,provided the original author and source are credited.
Med mindre annet er angitt, så er denne innførselen lisensiert som © 2017 Aakre et al. This is an open access article distributedunder the terms of the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproductionin any medium,provided the original author and source are credited.