Deterioration in muscle mass and physical function differs according to weight loss history in cancer cachexia
dc.contributor.author | Stene, Guro Birgitte | |
dc.contributor.author | Balstad, Trude Rakel | |
dc.contributor.author | Leer, Anne Silja Mäkitalo | |
dc.contributor.author | Bye, Asta | |
dc.contributor.author | Kaasa, Stein | |
dc.contributor.author | Fallon, Marie T. | |
dc.contributor.author | Laird, Barry J | |
dc.contributor.author | Maddocks, Matthew | |
dc.contributor.author | Solheim, Tora Skeidsvoll | |
dc.date.accessioned | 2019-12-12T12:33:44Z | |
dc.date.accessioned | 2019-12-13T09:40:01Z | |
dc.date.available | 2019-12-12T12:33:44Z | |
dc.date.available | 2019-12-13T09:40:01Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Stene, G.B., Balstad, T.R., Leer, A.S.M., Bye, A., Kaasa. S., Fallon, M.T. & Solheim, T.S. (2019). Deterioration in muscle mass and physical function differs according to weight loss history in cancer cachexia. Cancers, 11(12), E1925. doi:10.3390/cancers11121925 | en |
dc.identifier.issn | 2072-6694 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://hdl.handle.net/10642/7893 | |
dc.description.abstract | Background: Muscle mass and physical function (PF) are common co-primary endpoints in cancer cachexia trials, but there is a lack of data on how these outcomes interact over time. The aim of this secondary analysis of data from a trial investigating multimodal intervention for cancer cachexia (ClinicalTrials.gov: NCT01419145) is to explore whether changes in muscle mass and PF are associated with weight loss and cachexia status at baseline. Methods: Secondary analysis was conducted using data from a phase II randomized controlled trial including 46 patients with stage III–IV non-small cell lung cancer (n = 26) or inoperable pancreatic cancer (n = 20) due to commence chemotherapy. Cachexia status at baseline was classified according to international consensus. Muscle mass (assessed using computed tomography (CT)) and PF outcomes, i.e., Karnofsky performance status (KPS), self-reported PF (self-PF), handgrip strength (HGS), 6-minute walk test (6MWT), and physical activity (PA), were measured at baseline and after six weeks. Results: When compared according to cachexia status at baseline, patients with no/pre-cachexia had a mean loss of muscle mass (−5.3 cm2 , p = 0.020) but no statistically significant change in PF outcomes. Patients with cachexia also lost muscle mass but to a lesser extent (−2.8 cm2 , p = 0.146), but demonstrated a statistically significant decline in PF; KPS (−3.8 points, p = 0.030), self-PF (−8.8 points, p = 0.027), and HGS (−2.7 kg, p = 0.026). Conclusions: Weight loss history and cachexia status at baseline are of importance if one aims to detect changes in PF outcomes in cancer cachexia trials. To improve the use of co-primary endpoints that include PF in future trials, outcomes that have the potential to detect change relative to weight loss should be investigated further. | en |
dc.description.sponsorship | This research was funded by Liaison Committee for Education, Research and Innovation in Central Norway, Nordic Cancer Union, Norwegian Cancer Society and St Olav Cancer Fund. | |
dc.language.iso | en | en |
dc.publisher | MDPI | en |
dc.relation.ispartofseries | Cancers 2019;11(12) | |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Cachexia | en |
dc.subject | Weight loss | en |
dc.subject | Muscle mass | en |
dc.subject | Grip strength | en |
dc.subject | Physical performances | en |
dc.subject | Cancer | en |
dc.title | Deterioration in muscle mass and physical function differs according to weight loss history in cancer cachexia | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2019-12-12T12:33:44Z | |
dc.description.version | publishedVersion | en |
dc.identifier.doi | https://dx.doi.org/10.3390/cancers11121925 | |
dc.identifier.cristin | 1756272 | |
dc.source.journal | Cancers |
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HV - Institutt for sykepleie og helsefremmende arbeid [1386]
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Med mindre annet er angitt, så er denne innførselen lisensiert som © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).