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Common brain disorders are associated with heritable patterns of apparent aging of the brain

dc.contributor.authorKaufmann, Tobias
dc.contributor.authorvan der Meer, Dennis
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorSchwarz, Emanuel
dc.contributor.authorLund, Martina Jonette
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAlnæs, Dag
dc.contributor.authorBarch, Deanna M.
dc.contributor.authorBaur-Streubel, Ramona
dc.contributor.authorBertolino, Alessandro
dc.contributor.authorBettella, Francesco
dc.contributor.authorBeyer, Mona K.
dc.contributor.authorBøen, Erlend
dc.contributor.authorBorgwardt, Stefan
dc.contributor.authorBrandt, Christine Lycke
dc.contributor.authorBuitelaar, Jan
dc.contributor.authorCelius, Elisabeth Gulowsen
dc.contributor.authorCervenka, Simon
dc.contributor.authorConzelmann, Annette
dc.contributor.authorCòrdova Palomera, Aldo
dc.contributor.authorDale, Anders
dc.contributor.authorde Quervain, Dominique J.F.
dc.contributor.authordi Carlo, Pasquale
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDørum, Erlend Solberg
dc.contributor.authorEisenacher, Sarah
dc.contributor.authorElvsåshagen, Torbjørn
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorFatouros-Bergman, Helena
dc.contributor.authorFlyckt, Lena
dc.contributor.authorFranke, Barbara
dc.contributor.authorFrei, Oleksandr
dc.contributor.authorHaatveit, Beathe
dc.contributor.authorHåberg, Asta
dc.contributor.authorHarbo, Hanne Flinstad
dc.contributor.authorHartman, Catharina A
dc.contributor.authorHeslenfeld, Dirk J
dc.contributor.authorHoekstra, Pieter J
dc.contributor.authorHøgestøl, Einar August
dc.contributor.authorJernigan, Terry L.
dc.contributor.authorJonassen, Rune
dc.contributor.authorJönsson, Erik Gunnar
dc.contributor.authorKirsch, Peter
dc.contributor.authorKłoszewska, Iwona
dc.contributor.authorKolskår, Knut-Kristian
dc.contributor.authorLandrø, Nils Inge
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorLesch, Klaus-Peter
dc.contributor.authorLovestone, Simon
dc.contributor.authorLundervold, Arvid
dc.contributor.authorLundervold, Astri
dc.contributor.authorMaglanoc, Luigi Angelo
dc.contributor.authorMalt, Ulrik Fredrik
dc.contributor.authorMecocci, Patrizia
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorMoberget, Torgeir
dc.contributor.authorNorbom, Linn Christin Bonaventure
dc.contributor.authorNordvik, Jan Egil
dc.contributor.authorNyberg, Lars
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorPapalino, Marco
dc.contributor.authorPapassotiropoulos, Andreas
dc.contributor.authorPauli, Paul
dc.contributor.authorPergola, Giulio
dc.contributor.authorPersson, Karin Ester Torun
dc.contributor.authorRichard, Geneviève
dc.contributor.authorRokicki, Jaroslav
dc.contributor.authorSanders, Anne-Marthe
dc.contributor.authorSelbæk, Geir
dc.contributor.authorShadrin, Alexey A.
dc.contributor.authorSmeland, Olav Bjerkehagen
dc.contributor.authorSoininen, Hilkka
dc.contributor.authorSowa, Piotr
dc.contributor.authorSteen, Vidar Martin
dc.contributor.authorTsolaki, Magda
dc.contributor.authorUlrichsen, Kristine Moe
dc.contributor.authorVellas, Bruno
dc.contributor.authorWang, Lei
dc.contributor.authorWestman, Eric
dc.contributor.authorZiegler, Georg C.
dc.contributor.authorZink, Mathias
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorWestlye, Lars Tjelta
dc.date.accessioned2019-12-03T10:11:19Z
dc.date.accessioned2019-12-09T09:48:42Z
dc.date.available2019-12-03T10:11:19Z
dc.date.available2019-12-09T09:48:42Z
dc.date.issued2019-07-22
dc.identifier.citationKaufmann, T., van der Meer, D., Doan, N.T. et al. Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nat Neurosci 22, 1617–1623 (2019). https://doi.org/10.1038/s41593-019-0471-7en
dc.identifier.issn1097-6256
dc.identifier.issn1097-6256
dc.identifier.issn1546-1726
dc.identifier.urihttps://hdl.handle.net/10642/7874
dc.description.abstractCommon risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.en
dc.description.sponsorshipThe author list between I.A. and M.Z. is in alphabetic order. The authors were funded by the Research Council of Norway (276082 LifespanHealth (T.K.), 213837 (O.A.A), 223273 NORMENT (O.A.A.), 204966 (L.T.W.), 229129 (O.A.A.), 249795 (L.T.W.), 273345 (L.T.W.) and 283798 SYNSCHIZ (O.A.A.)), the South-Eastern Norway Regional Health Authority (2013-123 (O.A.A.), 2014-097 (L.T.W.), 2015-073 (L.T.W.) and 2016083 (L.T.W.)), Stiftelsen Kristian Gerhard Jebsen (SKGJ-MED-008), the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC Starting Grant, Grant agreement No. 802998 BRAINMINT (L.T.W.)), NVIDIA Corporation GPU Grant (T.K.), and the European Commission 7th Framework Programme (602450, IMAGEMEND (A.M.-L.)).en
dc.language.isoenen
dc.publisherNature Research (part of Springer Nature)en
dc.relation.ispartofseriesNature Neuroscience;Volume 22, Issue 10
dc.rightsOn author's personal website, institutional repository and funder designated repository after 6 months embargo.en
dc.subjectBrain age gapsen
dc.subjectBrain disordersen
dc.subjectGenetic architectureen
dc.subjectPleiotropyen
dc.titleCommon brain disorders are associated with heritable patterns of apparent aging of the brainen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2019-12-03T10:11:19Z
dc.description.versionacceptedVersionen
dc.identifier.doihttps://dx.doi.org/10.1038/s41593-019-0471-7
dc.identifier.cristin1717835
dc.source.journalNature Neuroscience
dc.relation.projectIDNorges forskningsråd: 276082
dc.relation.projectIDNorges forskningsråd: 249795


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