Language delay and poorer school performance in children of mothers with inadequate iodine intake in pregnancy: results from follow-up at 8 years in the Norwegian Mother and Child Cohort Study
dc.contributor.author | Abel, Marianne Hope | |
dc.contributor.author | Brandlistuen, Ragnhild Eek | |
dc.contributor.author | Caspersen, Ida Henriette | |
dc.contributor.author | Aase, Heidi | |
dc.contributor.author | Torheim, Liv Elin | |
dc.contributor.author | Meltzer, Helle Margrete | |
dc.contributor.author | Brantsæter, Anne Lise | |
dc.date.accessioned | 2018-12-10T12:18:24Z | |
dc.date.accessioned | 2019-02-12T07:25:41Z | |
dc.date.available | 2018-12-10T12:18:24Z | |
dc.date.available | 2019-02-12T07:25:41Z | |
dc.date.issued | 2018-11-12 | |
dc.identifier.citation | Abel MH, Brandlistuen RE, Caspersen IH, Aase H, Torheim LE, Meltzer HM, Brantsæter AL. Language delay and poorer school performance in children of mothers with inadequate iodine intake in pregnancy: results from follow-up at 8 years in the Norwegian Mother and Child Cohort Study. European Journal of Nutrition. 2018 | en |
dc.identifier.issn | 1436-6207 | |
dc.identifier.issn | 1436-6207 | |
dc.identifier.issn | 1436-6215 | |
dc.identifier.uri | https://hdl.handle.net/10642/6611 | |
dc.description.abstract | Purpose Some studies indicate that mild-to-moderate iodine deficiency in pregnant women might negatively affect offspring neurocognitive development, including previous results from the Norwegian Mother and Child Cohort study (MoBa) exploring maternally reported child development at age 3 years. The aim of this follow-up study was to investigate whether maternal iodine intake in pregnancy is associated with language and learning at 8 years of age. Methods The study sample includes 39,471 mother–child pairs participating in MoBa with available information from a validated food frequency questionnaire covering the first half of pregnancy and a questionnaire on child neurocognitive development at 8 years. Multivariable regression was used to explore associations of iodine intake from food and supplements with maternally reported child outcomes. Results Maternal iodine intake from food less than ~ 150 µg/day was associated with poorer child language skills (p-overall = 0.013), reading skills (p-overall = 0.019), and writing skills (p-overall = 0.004) as well as poorer school test result in reading (p < 0.001), and increased likelihood of the child receiving special educational services (p-overall = 0.042) (in noniodine supplement users). Although significant, differences were generally small. Maternal use of iodine supplements in pregnancy was not significantly associated with any of the outcomes. Conclusions Low habitual iodine intake in pregnant women, i.e., lower than the recommended intake for non-pregnant women, was associated with mothers reporting poorer child language, school performance, and increased likelihood of special educational services. We found no indications of benefits or harm of using iodine-containing supplements in pregnancy. Initiating use in pregnancy might be too late. | en |
dc.description.sponsorship | The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/ NIEHS (contract no N01-ES-75558), NIH/NINDS (Grant no. 1 UO1 NS 047537-01 and Grant no. 2 UO1 NS 047537-06A1). MHA was supported by a 4 years Grant from the Norwegian Research Council (Grant no. 241430) and the Norwegian dairy company TINE SA. | en |
dc.language.iso | en | en |
dc.publisher | Springer | en |
dc.relation.ispartofseries | European Journal of Nutrition; | |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Iodine | en |
dc.subject | Pregnancies | en |
dc.subject | Dietary supplements | en |
dc.subject | Neurodevelopments | en |
dc.subject | Mother and child cohort studies | en |
dc.title | Language delay and poorer school performance in children of mothers with inadequate iodine intake in pregnancy: results from follow-up at 8 years in the Norwegian Mother and Child Cohort Study | en |
dc.type | Journal article | |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2018-12-10T12:18:24Z | |
dc.description.version | publishedVersion | en |
dc.identifier.doi | http://dx.doi.org/10.1007/s00394-018-1850-7 | |
dc.identifier.cristin | 1635056 | |
dc.source.journal | European Journal of Nutrition |
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