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dc.contributor.authorHenjum, Sigrun
dc.contributor.authorKvestad, Ingrid
dc.contributor.authorShrestha, Merina
dc.contributor.authorUlak, Manjeswori
dc.contributor.authorChandyo, Ram K.
dc.contributor.authorThorne-Lyman, Andrew L.
dc.contributor.authorShrestha, Prakash S.
dc.contributor.authorKjellevold, Marian
dc.contributor.authorHysing, Mari
dc.contributor.authorStrand, Tor A.
dc.date.accessioned2018-08-26T06:43:52Z
dc.date.accessioned2018-08-28T07:01:15Z
dc.date.available2018-08-26T06:43:52Z
dc.date.available2018-08-28T07:01:15Z
dc.date.issued2018-07-19
dc.identifier.citationHenjum S, Kvestad I, Shrestha M, Ulak M, Chandyo RK, Thorne-Lyman AL, Shrestha PS, Kjellevold MK, Hysing M, Strand TA. Erythrocyte DHA and AA in infancy is not associated with general development five years later in Nepalese children. Nutrition Journal. 2018;17(1)en
dc.identifier.issn1475-2891
dc.identifier.issn1475-2891
dc.identifier.urihttps://hdl.handle.net/10642/6093
dc.description.abstractBackground: Long chain polyunsaturated fatty acids (LCPUFA) especially docosahexaenoic acid (DHA) and arachidonic acid (AA) are crucial for normal brain development in utero and in early infancy. Data on fatty acid status and cognitive development in infants and children from low-income countries are scarce. Methods: We examined the association between the DHA and AA status in infancy (n=320) and developmental status and cognitive functioning five years later. At five years of age, we measured development by the Ages and Stages Questionnaire 3rd. ed. (ASQ-3) and cognitive functioning by subtests from the neuropsychological test battery NEPSY II. In addition, infant fatty acid composition in red blood cells (RBC) was analyzed. In multiple linear and logistic regression models, we estimated the associations between DHA and AA status in infancy and scores on the ASQ-3 and the NEPSY II subtests. Results: There were no notable associations between infant AA and DHA status, and the scores on the ASQ-3 and the NEPSY II subtests five years later. It should be noted that we found better than expected concentrations of erythrocyte DHA and AA among the infants, and the ASQ scores were left-skewed, which limited the ability to identify associations. Conclusion: DHA and AA status in infancy is seemingly not related to neurodevelopment measured 5 years later in this peri-urban population from Nepal.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.ispartofseriesNutrition Journal;17:70
dc.rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPolyunsaturated fatty acidsen
dc.subjectPlasma phospholipidsen
dc.subjectDevelopmental statusesen
dc.subjectCognitive functioningen
dc.subjectFollow up-studiesen
dc.subjectNepalese childrenen
dc.titleErythrocyte DHA and AA in infancy is not associated with developmental status and cognitive functioning five years later in Nepalese childrenen
dc.title.alternativeErythrocyte DHA and AA in infancy is not associated with general development five years later in Nepalese childrenen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2018-08-26T06:43:52Z
dc.description.versionpublishedVersionen
dc.identifier.doihttp://dx.doi.org/10.1186/s12937-018-0375-5
dc.identifier.cristin1604521
dc.source.journalNutrition Journal


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© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Med mindre annet er angitt, så er denne innførselen lisensiert som © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.