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dc.contributor.authorMarsdal, Kjersti Engen
dc.contributor.authorSørbye, Ingvil
dc.contributor.authorGaudernack, Lise Christine
dc.contributor.authorLukasse, Mirjam
dc.date.accessioned2018-02-22T09:41:40Z
dc.date.accessioned2018-06-19T12:56:37Z
dc.date.available2018-02-22T09:41:40Z
dc.date.available2018-06-19T12:56:37Z
dc.date.issued2018-01-05
dc.identifier.citationMarsdal KE, Sørbye I, Gaudernack LC, Lukasse M. A comparison of misoprostol vaginal insert and misoprostol vaginal tablets for induction of labor in nulliparous women: a retrospective cohort study. BMC Pregnancy and Childbirth. 2018;18(1)en
dc.identifier.issn1471-2393
dc.identifier.issn1471-2393
dc.identifier.urihttps://hdl.handle.net/10642/5971
dc.description.abstractBackground: Since Misoprostol Vaginal Insert (MVI - Misodel ®) was approved for labor induction in Europe in 2013, to date, no study has been published comparing MVI to Misoprostol vaginal tablets (MVT). The aim of this study, performed as part of a quality improvement project, was to compare the efficacy and safety of 200 μg MVI versus 25 μg MVT for labor induction in nulliparous women. Methods: This retrospective cohort study included 171 nulliparous singleton term deliveries induced with MVI (n=85) versus MVT (n=86) at Oslo University Hospital Rikshospitalet, Norway, from November 2014 to December 2015. Primary outcomes were time from drug administration to delivery in hours and minutes and the rate of cesarean section (CS). Results were adjusted for Bishop Score and pre-induction with balloon catheter. Results: Median time from drug administration to delivery was shorter in the MVI group compared to the MVT group (15 h 43 min versus 19 h 37 min, p=0.011). Adjusted for confounding factors, mean difference was 6 h 3 min (p=0.002). The risk of CS was 67% lower in the MVI group compared to the MVT group (11.8% versus 23.3%, OR=0.33; adjusted 95% CI 0.13–0.81). Adverse neonatal outcomes did not differ between the groups. Conclusions: In a setting of routine obstetric care, MVI seems to be a more efficient labor induction agent than MVT, and with a lower CS rate and no increase in adverse infant outcomes.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.ispartofseriesBMC Pregnancy and Childbirth;Volume 18, 18:11
dc.rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectLabor inductionen
dc.subjectCervical ripeningsen
dc.subjectMisoprostolen
dc.subjectNulliparityen
dc.titleA comparison of misoprostol vaginal insert and misoprostol vaginal tablets for induction of labor in nulliparous women: a retrospective cohort studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2018-02-22T09:41:40Z
dc.description.versionpublishedVersionen
dc.identifier.doihttps://doi.org/10.1186/s12884-017-1647-3
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dc.source.journalBMC Pregnancy and Childbirth


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© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.