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dc.contributor.authorDeyab, Gia
dc.contributor.authorHokstad, Ingrid
dc.contributor.authorWhist, Jon Elling
dc.contributor.authorSmåstuen, Milada C
dc.contributor.authorAgewall, Stefan
dc.contributor.authorLyberg, Torstein
dc.contributor.authorRonda, Nicoletta
dc.contributor.authorMikkelsen, Knut
dc.contributor.authorHjeltnes, Gunnbjørg
dc.contributor.authorHollan, Ivana
dc.date.accessioned2018-03-06T09:09:53Z
dc.date.accessioned2018-06-18T11:59:14Z
dc.date.available2018-03-06T09:09:53Z
dc.date.available2018-06-18T11:59:14Z
dc.date.issued2017-10-17
dc.identifier.citationDeyab G, Hokstad I, Whist Je, Småstuen MC, Agewall S, Lyberg T, Ronda N, Mikkelsen K, Hjeltnes G, Hollan I. Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis. Arthritis Research & Therapy. 2017;19:232:1-10en
dc.identifier.issn1478-6362
dc.identifier.issn1478-6362
dc.identifier.urihttps://hdl.handle.net/10642/5964
dc.description.abstractBackground: Inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), leads to increased cardiovascular disease occurrence probably due to atherosclerosis. One of the first stages in atherogenesis is endothelial dysfunction (ED). Therefore, we aimed to compare endothelial function (EF) in patients with IA, and to examine the effects of methotrexate (MTX) monotherapy and antitumor necrosis factor (anti-TNF) treatment with or without MTX comedication (anti-TNF±MTX) on EF. Methods: From the PSARA observational study, all patients with RA (n=64), PsA (n=29), and AS (n=20) were evaluated for EF. In patients with ED at baseline (n=40), we evaluated changes in the Reactive Hyperemic Index (RHI) after 6 weeks and 6 months of antirheumatic therapy. Results: In IA patients with ED, RHI significantly improved after 6 weeks (p<0.001) and 6 months (p<0.001) of treatment, independent of changes in disease activity parameters. After 6 months, RHI had improved more in the MTX group than in the anti-TNF±MTX group, and the difference remained statistically significant after adjustments for potential confounders. Among patients with active RA, AS, and PsA, those with AS appeared to have the worst endothelial function, although they were the youngest. Conclusion: Treatment with MTX and anti-TNF±MTX was associated with a relatively fast improvement of EF in IA patients with ED, independent of change in disease activity. Therefore, modes of action other than the antiinflammatory effect may contribute to the EF improvement. After 6 months, the EF improvement was more pronounced in the MTX group than in the anti-TNF±MTX group.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.ispartofseriesArthritis Research & Therapy;Volume 19: 232
dc.rights© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMethotrexateen
dc.subjectInflammatory arthritisen
dc.subjectAnti-tumor necrosis factorsen
dc.subjectRheumatic arthritisen
dc.titleMethotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritisen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2018-03-06T09:09:53Z
dc.description.versionpublishedVersionen
dc.identifier.doihttps://doi.org/10.1186/s13075-017-1439-1
dc.identifier.cristin1521997
dc.source.journalArthritis Research & Therapy


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© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Med mindre annet er angitt, så er denne innførselen lisensiert som © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.