A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer
dc.contributor.author | Solheim, Tora Skeidsvoll | |
dc.contributor.author | Laird, Barry J | |
dc.contributor.author | Balstad, Trude Rakel | |
dc.contributor.author | Stene, Guro Birgitte | |
dc.contributor.author | Bye, Asta | |
dc.contributor.author | Johns, Neil | |
dc.contributor.author | Pettersen, Caroline Hild Hakvåg | |
dc.contributor.author | Fallon, Marie | |
dc.contributor.author | Fayers, Peter | |
dc.contributor.author | Fearon, Kenneth | |
dc.contributor.author | Kaasa, Stein | |
dc.date.accessioned | 2018-01-12T11:23:50Z | |
dc.date.accessioned | 2018-03-19T10:03:38Z | |
dc.date.available | 2018-01-12T11:23:50Z | |
dc.date.available | 2018-03-19T10:03:38Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Solheim TS, Laird BJ, Balstad TR, Stene GB, Bye A, Johns N, Pettersen CH, Fallon M, Fayers P, Fearon K, Kaasa S. A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer. Journal of Cachexia, Sarcopenia and Muscle. 2017;8:778-788 | en |
dc.identifier.issn | 2190-5991 | |
dc.identifier.issn | 2190-6009 | |
dc.identifier.uri | https://hdl.handle.net/10642/5764 | |
dc.description.abstract | Background Cancer cachexia is a syndrome of weight loss (including muscle and fat), anorexia, and decreased physical function. It has been suggested that the optimal treatment for cachexia should be a multimodal intervention. The primary aim of this study was to examine the feasibility and safety of a multimodal intervention (n‐3 polyunsaturated fatty acid nutritional supplements, exercise, and anti‐inflammatory medication: celecoxib) for cancer cachexia in patients with incurable lung or pancreatic cancer, undergoing chemotherapy. Methods Patients receiving two cycles of standard chemotherapy were randomized to either the multimodal cachexia intervention or standard care. Primary outcome measures were feasibility assessed by recruitment, attrition, and compliance with intervention (>50% of components in >50% of patients). Key secondary outcomes were change in weight, muscle mass, physical activity, safety, and survival. Results Three hundred and ninety‐nine were screened resulting in 46 patients recruited (11.5%). Twenty five patients were randomized to the treatment and 21 as controls. Forty‐one completed the study (attrition rate 11%). Compliance to the individual components of the intervention was 76% for celecoxib, 60% for exercise, and 48% for nutritional supplements. As expected from the sample size, there was no statistically significant effect on physical activity or muscle mass. There were no intervention‐related Serious Adverse Events and survival was similar between the groups. Conclusions A multimodal cachexia intervention is feasible and safe in patients with incurable lung or pancreatic cancer; however, compliance to nutritional supplements was suboptimal. A phase III study is now underway to assess fully the effect of the intervention. | en |
dc.language.iso | en | en |
dc.publisher | Wiley Open Access | en |
dc.rights | © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wa sting Disorders Journal of Cachexia, Sarcopenia and Muscle 2017; 8 : 778 – 788 Published online 14 June 2017 in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/jcsm.12201 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribut ion in any medium, provided the original work is properly cited, the use is non-commercial and no modi fi cations or adaptations are made. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Cachexia | en |
dc.subject | Cancer | en |
dc.subject | Randomised | en |
dc.subject | Multi-modal | en |
dc.subject | Trial | en |
dc.subject | Anti-inflammatory | en |
dc.title | A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2018-01-12T11:23:50Z | |
dc.description.version | publishedVersion | en |
dc.subject.hrcs | Kreft: Legemidler | |
dc.subject.hrcs | Cancer : Pharmaceuticals | |
dc.identifier.cristin | 1515951 | |
dc.source.journal | Journal of Cachexia, Sarcopenia and Muscle |
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HV - Institutt for sykepleie og helsefremmende arbeid [1386]
HV - Department of Nursing and Health Promotion
Med mindre annet er angitt, så er denne innførselen lisensiert som © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wa
sting Disorders
Journal of Cachexia, Sarcopenia and Muscle
2017;
8
: 778
–
788
Published online 14 June 2017 in Wiley Online Library (wileyonlinelibrary.com)
DOI:
10.1002/jcsm.12201
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribut
ion in any medium,
provided the original work is properly cited, the use is non-commercial and no modi
fi
cations or adaptations are made.