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dc.contributor.authorBye, Asta
dc.contributor.authorSjøblom, Bjørg
dc.contributor.authorWentzel-Larsen, Tore
dc.contributor.authorGrønberg, Bjørn Henning
dc.contributor.authorBaracos, Vickie E.
dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorAass, Nina Kathrine
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorFløtten, Øystein
dc.contributor.authorJordhøy, Marit Slaaen
dc.date.accessioned2018-01-11T12:31:09Z
dc.date.accessioned2018-03-14T10:56:58Z
dc.date.available2018-01-11T12:31:09Z
dc.date.available2018-03-14T10:56:58Z
dc.date.issued2017
dc.identifier.citationBye A, Sjøblom B, Wentzel-Larsen T, Grønberg BH, Baracos VE, Hjermstad MJ, Aass NK, Bremnes RM, Fløtten Ø, Jordhøy MS. Muscle mass and association to quality of life in non-small cell lung cancer patients. Journal of Cachexia, Sarcopenia and Muscle. 2017;8:759-767en
dc.identifier.issn2190-5991
dc.identifier.issn2190-6009
dc.identifier.urihttps://hdl.handle.net/10642/5757
dc.description.abstractBackground Cancer wasting is characterized by muscle loss and may contribute to fatigue and poor quality of life (QoL). Our aim was to investigate associations between skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) and selected QoL outcomes in advanced non-small cell lung cancer (NSCLC) at diagnosis. Methods Baseline data from patients with stage IIIB/IV NSCLC and performance status 0–2 enrolled in three randomized trials of first-line chemotherapy (n = 1305) were analysed. Associations between SMI (cm2/m2) and SMD (Hounsfield units) based on computed tomography-images at the third lumbar level and self-reported physical function (PF), role function (RF), global QoL, fatigue, and dyspnoea were investigated by linear regression using flexible non-linear modelling. Results Complete data were available for 734 patients, mean age 65 years. Mean SMI was 47.7 cm2/m2 in men (n = 420) and 39.6 cm2/m2 in women (n = 314). Low SMI values were non-linearly associated with low PF and RF (men P = 0.016/0.020, women P = 0.004/0.012) and with low global QoL (P = 0.001) in men. Low SMI was significantly associated with high fatigue (P = 0.002) and more pain (P = 0.015), in both genders, but not with dyspnoea. All regression analyses showed poorer physical outcomes below an SMI breakpoint of about 42–45 cm2/m2 for men and 37–40 cm2/m2 for women. In both genders, poor PF and more dyspnoea were significantly associated with low SMD. Conclusions Low muscle mass in NSCLC negatively affects the patients' PF, RF, and global QoL, possibly more so in men than in women. However, muscle mass must be below a threshold value before this effect can be detected.en
dc.language.isoenen
dc.publisherWiley Open Accessen
dc.rights© 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNon-small cell lung canceren
dc.subjectQuality of lifeen
dc.subjectBody compositionen
dc.subjectMuscle massen
dc.titleMuscle mass and association to quality of life in non-small cell lung cancer patientsen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2018-01-11T12:31:09Z
dc.description.versionpublishedVersionen
dc.identifier.doihttp://doi.org/10.1002/jcsm.12206
dc.identifier.cristin1515725
dc.source.journalJournal of Cachexia, Sarcopenia and Muscle


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© 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Med mindre annet er angitt, så er denne innførselen lisensiert som © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.