Vis enkel innførsel

dc.contributor.authorMolin, Marianne
dc.contributor.authorUlven, Stine Marie
dc.contributor.authorDahl, Lisbeth
dc.contributor.authorHaldorsen, Anne-Katrine L.
dc.contributor.authorHolck, Marianne
dc.contributor.authorAlexander, Jan
dc.contributor.authorMeltzer, Helle Margrete
dc.contributor.authorYdersbond, Trond A.
dc.date.accessioned2017-11-03T08:04:15Z
dc.date.accessioned2018-01-04T08:48:36Z
dc.date.available2017-11-03T08:04:15Z
dc.date.available2018-01-04T08:48:36Z
dc.date.issued2017
dc.identifier.citationMolin M, Ulven S, Dahl L, Haldorsen AK, Holck M, Alexander J, Meltzer HM, Ydersbond TA. Arsenic in seafood is associated with increased thyroid-stimulating hormone (TSH) in healthy volunteers ? A randomized controlled trial. Journal of Trace Elements in Medicine and Biology. 2017;44:1-7en
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.urihttps://hdl.handle.net/10642/5434
dc.description.abstractBackground Exposure to exogenous elements like arsenic (As) may influence thyroid enzymes, thyroid-stimulating hormone (TSH), and the two principal thyroid hormones, free thyroxine (FT4) and free triiodothyronine (FT3), but little is known about how this is related to organic arsenicals, the main form in seafood. Aim To investigate whether a high intake of dietary arsenic from seafood can impact thyroid function and thyroid hormones by examining possible associations with changes in TSH, FT4, FT3 and the FT4:FT3-ratio in plasma. Methods Thirty-eight healthy subjects were randomized into four groups. During a 14-day semi-controlled dietary study, the subjects ingested daily portions of either 150 g cod, salmon, blue mussels or potato (control). Plasma concentrations of total As, FT3, FT4, TSH and selenium (Se), and urinary concentrations of iodine were monitored. Results Plasma concentrations of TSH increased significantly in all seafood groups. The change in plasma As, with different coefficients for each seafood group, was the dominant factor in the optimal multiple regression model for change in TSH (R2 = 0.47). Plasma Se and iodine were negative and positive factors, respectively. There were also indications of changes in FT4, FT3 and the FT4:FT3 ratio consistent with a net inhibiting effect of As on FT4 to FT3 conversion. Conclusion Ingestion of seafood rich in various organic As species was strongly associated with an increase of the TSH concentrations in plasma. Change in TSH was positively associated with total plasma As, but varied with the type of seafood ingested. These findings indicate that organic dietary As, apparently depending on chemical form, may influence thyroid hormones and function.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsPostprint version of published article is published under the CC-BY-NC-ND licenseen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleArsenic in seafood is associated with increased thyroid-stimulating hormone (TSH) in healthy volunteers ? A randomized controlled trialen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2017-11-03T08:04:15Z
dc.description.versionacceptedVersionen
dc.identifier.doihttp://doi.org/10.1016/j.jtemb.2017.05.004
dc.identifier.cristin1486302
dc.source.journalJournal of Trace Elements in Medicine and Biology


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Postprint version of published article is published under the CC-BY-NC-ND license
Med mindre annet er angitt, så er denne innførselen lisensiert som Postprint version of published article is published under the CC-BY-NC-ND license