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dc.contributor.authorMorland, Cecilie
dc.contributor.authorAndersson, Krister
dc.contributor.authorHaugen, Øyvind Pernell
dc.contributor.authorHadzic, Alena
dc.contributor.authorKleppa, Liv
dc.contributor.authorGille, Andreas
dc.contributor.authorRinholm, Johanne Egge
dc.contributor.authorPalibrk, Vuk
dc.contributor.authorDiget, Elisabeth Holm
dc.contributor.authorKennedy, Lauritz Hagen
dc.contributor.authorStølen, Tomas
dc.contributor.authorHennestad, Eivind
dc.contributor.authorMoldestad, Olve
dc.contributor.authorCai, Yiqing
dc.contributor.authorPuchades, Maja Amedjkouh
dc.contributor.authorOffermanns, Stefan
dc.contributor.authorVervaeke, Koen Gerard Alois
dc.contributor.authorBjørås, Magnar
dc.contributor.authorWisløff, Ulrik
dc.contributor.authorStorm-Mathisen, Jon
dc.contributor.authorBergersen, Linda Hildegard
dc.date.accessioned2017-08-14T14:23:07Z
dc.date.accessioned2017-09-04T11:28:23Z
dc.date.available2017-08-14T14:23:07Z
dc.date.available2017-09-04T11:28:23Z
dc.date.issued2017
dc.identifier.citationMorland C, Andersson K, Haugen ØP, Hadzic A, Kleppa L, Gille A, Rinholm JE, Palibrk V, Diget EH, Kennedy LH, Stølen TS, Hennestad E, Moldestad O, Cai Y, Puchades M, Offermanns S, Vervaeke KGA, Bjørås M, Wisløff U, Storm-Mathisen J, Bergersen LH. Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communications. 2017;8language
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/10642/5192
dc.description.abstractPhysical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-like cells along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) and cerebral angiogenesis. High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle shows no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. Thus, we demonstrate that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor.language
dc.language.isoenlanguage
dc.publisherNature Publishing Grouplanguage
dc.rightsCreative Commons Attribution License 4.0language
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCirculationlanguage
dc.subjectExerciselanguage
dc.subjectReceptorslanguage
dc.titleExercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1language
dc.typeJournal articlelanguage
dc.typePeer reviewedlanguage
dc.date.updated2017-08-14T14:23:06Z
dc.description.versionpublishedVersionlanguage
dc.identifier.doihttp://doi.org/10.1038/ncomms15557
dc.identifier.cristin1483542
dc.source.journalNature Communications


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