Comparison of bioavailability of krill oil versus fish oil and health effect
dc.contributor.author | Ulven, Stine Marie | |
dc.contributor.author | Holven, Kirsten Bjørklund | |
dc.date.accessioned | 2017-05-03T11:58:47Z | |
dc.date.accessioned | 2017-05-16T12:17:07Z | |
dc.date.available | 2017-05-03T11:58:47Z | |
dc.date.available | 2017-05-16T12:17:07Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Ulven S, Holven KB. Comparison of bioavailability of krill oil versus fish oil and health effect. Vascular Health and Risk Management. 2015;11:511-524 | language |
dc.identifier.issn | 1178-2048 | |
dc.identifier.uri | https://hdl.handle.net/10642/4986 | |
dc.description.abstract | Background: The aim of this review is to summarize the effects of krill oil (KO) or fish oil (FO) on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) incorporation in plasma phospholipids or membrane of red blood cells (RBCs) as shown in human and animal studies. Furthermore, we discuss the findings in relation to the possible different health effects, focusing on lipids, inflammatory markers, cardiovascular disease risk, and biological functions of these two sources of long-chain n-3 polyunsaturated fatty acids (PUFAs). Methods: A literature search was conducted in PubMed in January 2015. In total, 113 articles were identified, but based on selection criteria, 14 original papers were included in the review. Results: Studies on bioavailability of EPA and DHA from KO and FO in humans and animals are limited and the interpretation is difficult, as different amounts of EPA and DHA have been used, duration of intervention differs, and different study groups have been included. Two human studies – one postprandial study and one intervention study – used the same amount of EPA and DHA from KO or FO, and they both showed that the bioavailability of EPA and DHA from KO seems to be higher than that from FO. Limited effects of KO and FO on lipids and inflammatory markers in human and animal studies were reported. Gene expression data from animal studies showed that FO upregulated the cholesterol synthesis pathway, which was the opposite of the effect mediated by KO. KO also regulated far more metabolic pathways than FO, which may indicate different biological effects of KO and FO. Conclusion: There seems to be a difference in bioavailability of EPA and DHA after intake of KO and FO, but more studies are needed before a firm conclusion can be made. It is also necessary to document the beneficial health effects of KO with more human studies and to elucidate if these effects differ from those after regular fish and FO intake. | language |
dc.language.iso | en | language |
dc.publisher | Dove press | language |
dc.rights | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. | language |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | |
dc.subject | Human studies | language |
dc.subject | Gene expressions | language |
dc.subject | Fatty acids | language |
dc.subject | Cardiovascular disease | language |
dc.title | Comparison of bioavailability of krill oil versus fish oil and health effect | language |
dc.type | Journal article | language |
dc.type | Peer reviewed | language |
dc.date.updated | 2017-05-03T11:58:47Z | |
dc.description.version | publishedVersion | language |
dc.identifier.doi | http://doi.org/10.2147/VHRM.S85165 | |
dc.identifier.cristin | 1281374 |
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Except where otherwise noted, this item's license is described as This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.