Akershus Universitetssykehus HF: Recent submissions

Now showing items 101-120 of 153

    • Factors associated with life-sustaining treatment restriction in a general intensive care unit 

      Skjaker, Stein Arve; Hoel, Henrik; Dahl, Vegard; Stavem, Knut (PloS one;12(7), Journal article; Peer reviewed, 2017-07-18)
      Abstract Purpose Few previous studies have investigated associations between clinical variables available after 24 hours in the intensive care unit (ICU), including the Charlson Comorbidity Index (CCI), and decisions to ...

    • Impaired synaptic function is linked to cognition in Parkinson's disease 

      Selnes, Per; Stav, Ane Løvli; Johansen, Krisztina Kunszt; Bjørnerud, Atle; Coello, Sebastien Christopher; Auning, Eirik; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Hessen, Erik; Zetterberg, Henrik; Blennow, Kaj; Årsland, Dag; Fladby, Tormod (Annals of Clinical and Translational Neurology;4(10), Journal article; Peer reviewed, 2017-08-31)
      Objective Cognitive impairment is frequent in Parkinson's disease, but the underlying mechanisms are insufficiently understood. Because cortical metabolism is reduced in Parkinson's disease and closely associated with ...

    • Prevalence of posttraumatic stress disorder in persons with chronic pain: A meta-analysis 

      Siqveland, Johan; Hussain, Ajmal; Lindstrøm, Jonas Christoffer; Ruud, Torleif; Hauff, Edvard (Frontiers in Psychiatry;8, Journal article; Peer reviewed, 2017-09-14)
      Objective: To summarize evidence for the prevalence of posttraumatic stress disorder (PTSD) among persons with chronic pain (CP). Methods: We searched databases for studies published between January 1995 and December ...

    • A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America 

      Rossi, Benedito Mauro; Palmero, Edenir Inêz; López-Kostner, Francisco; Sarroca, Carlos; Vaccaro, Carlos Alberto; Spirandelli, Florencia; Ashton-Prolla, Patricia; Rodriguez, Yenni; Galvão, Henrique de Campos Reis; Reis, Rui Manuel; dePaula, André Escremim; Romagnolo, Luis Gustavo Capochin; Alvarez, Karin; Valle, Adriana Della; Neffa, Florencia; Kalfayan, Pablo German; Spirandelli, Enrique; Chialina, Sergio; Angulo, Melva Gutiérrez; Castro-Mujica, Maria del Carmen; de Monte, Julio Sanchez; Quispe, Richard; de Silva, Sabrina Daniela; Rossi, Norma Teresa; Barletta-Carrillo, Claudia; Revollo, Susann; Taborga, Ximena; Morillas, L. Lena; Tubeuf, Hélène; Monteiro-Santos, Erika Maria; Piñero, Tamara Alejandra; Dominguez-Barrera, Constantino; Wernhoff, Patrik; Martins, Alexandra; Hovig, Eivind; Møller, Pål; Valentin, Mev Dominguez (BMC cancer;17(1), Journal article; Peer reviewed, 2017-09-05)
      Background Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants ...

    • Community treatment orders and social outcomes for patients with psychosis: a 48-month follow-up study 

      Vergunst, Francis; Rugkåsa, Jorun; Koshiaris, Constantinos; Simon, Judit; Burns, Tom (Social Psychiatry and Psychiatric Epidemiology;52(11), Journal article; Peer reviewed, 2017-09-12)
      PURPOSE: Community treatment orders (CTOs) are widely used internationally despite a lack of evidence supporting their effectiveness. Most effectiveness studies are relatively short (12-months or less) and focus on clinical ...

    • A prospective, quantitative study of mental health act assessments in England following the 2007 amendments to the 1983 act: Did the changes fulfill their promise? 

      Singh, Swaran P; Paul, Moli; Parsons, Helen; Burns, Tom; Pyrer, Peter; Fazel, Seena; Deb, Shoumitro; Islam, Zoebia; Rugkåsa, Jorun; Gajwani, Ruchika; Thana, Lavanya; Crawford, Michael J (BMC psychiatry;17(1), Journal article; Peer reviewed, 2017-07-10)
      Background In 2008, the Mental Health Act (MHA) 2007 amendments to the MHA 1983 were implemented in England and Wales. The amendments were intended to remove perceived obstacles to the detention of high risk patients with ...

    • Genotypic characterization of gentamicin and cephalosporin 1 resistant Escherichia coli 2 isolates from blood cultures in a Norwegian university hospital 2011-2015 

      Fladberg, Øyvind Andreas; Jørgensen, Silje; Aamot, Hege Vangstein (Antimicrobial Resistance & Infection Control;121(6), Journal article; Peer reviewed, 2017-11-29)
      Background: Cephalosporin resistance in clinical E. coli isolates is increasing internationally. The increase has been caused by virulent and often multidrug-resistant clones, especially the extended spectrum beta-lactamase ...

    • Early warning- and track and trigger systems for newborn infants: A review 

      Mortensen, Nicolay; Augustsson, Johan Henrik; Ulriksen, Jorunn; Hinna, Unni Tveit; Schmölzer, Georg M. (Journal of Child Health Care;21(1), Journal article; Peer reviewed, 2017-01-19)
      Tools for clinical assessment and escalation of observation and treatment are insufficiently established in the newborn population. We aimed to provide an overview over early warning- and track and trigger systems for ...

    • Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma 

      Bäckryd, Emmanuel; Tanum, Lars Håkon Reiestad; Lind, Anne-Li; Larsson, Anders; Gordh, Torsten (Journal of Pain Research;10, Journal article; Peer reviewed, 2017-03-03)
      Abstract: In addition to central hyperexcitability and impaired top–down modulation, chronic inflammation probably plays a role in the pathophysiology of fibromyalgia (FM). Indeed, on the basis of both animal experiments ...

    • Cognitive deficits in chronic stroke patients: neuropsychological assessment, depression, and self-reports 

      Nakling, Arne; Årsland, Dag; Næss, Halvor; Wollschläger, Daniel; Fladby, Tormod; Hofstad, Håkon; Eike, Wehling (Dementia and Geriatric Cognitive Disorders Extra;7(2), Journal article; Peer reviewed, 2017)
      Background: Following stroke, clinicians are challenged to detect and untangle symptoms of cognitive dysfunction and mood disorders. Additionally, they need to evaluate the informative value of self-reports to identify ...

    • Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification 

      Rutkovskiy, Arkady; Malashicheva, Anna; Sullivan, Gareth; Bogdanova, Mariia; Kostareva, Anna; Stensløkken, Kåre-Olav; Fiane, Arnt E; Vaage, Ingvar Jarle (Journal of The American Heart Association;6(9), Journal article; Peer reviewed, 2017-09-22)
      Aortic valve stenosis due to calcification of the valve leaflets is the most common valve disease in the developed world. It is the third leading cause of cardiovascular disease.1 Risk factors include male gender, smoking, ...

    • Post-traumatic stress disorder moderates the relationship between trauma exposure and chronic pain 

      Siqveland, Johan; Ruud, Torleif; Hauff, Edvard (European Journal of Psychotraumatology;8(1), Journal article; Peer reviewed, 2017-09-19)
      Background: Trauma exposure and post-traumatic stress disorder (PTSD) are risk factors for chronic pain. Objective: This study investigated how exposure to intentional and non-intentional traumatic events and PTSD are ...

    • Extending XNAT platform with an incremental semantic framework 

      Reina, Santiago Timon; Rincón, Mariano; Martinez-Tomás, Rafael (Frontiers in Neuroinformatics;11, Journal article; Peer reviewed, 2017-08-31)
      Informatics increases the yield from neuroscience due to improved data. Data sharing and accessibility enable joint efforts between different research groups, as well as replication studies, pivotal for progress in the ...

    • Charlson comorbidity index derived from chart review or administrative data: Agreement and prediction of mortality in intensive care patients 

      Stavem, Knut; Hoel, Henrik; Skjaker, Stein Arve; Haagensen, Rolf E (Clinical Epidemiology;9, Journal article; Peer reviewed, 2017-06-02)
      Purpose: This study compared the Charlson comorbidity index (CCI) information derived from chart review and administrative systems to assess the completeness and agreement between scores, evaluate the capacity to predict ...

    • Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD 

      Skjørten, Ingunn; Hilde, Janne Mykland; Melsom, Morten Nissen; Hisdal, Jonny; Hansteen, Viggo; Steine, Kjetil; Humerfelt, Sjur (International Journal of Chronic Obstructive Pulmonary Disease;13, Journal article; Peer reviewed, 2017-08-26)
      Background: Exercise tolerance decreases as COPD progresses. Pulmonary hypertension (PH) is common in COPD and may reduce performance further. COPD patients with and without PH could potentially be identified by cardiopulmonary ...

    • Biomarkers in subtypes of mild cognitive impairment and subjective cognitive decline 

      Eliassen, Carl F Andestad; Reinvang, Ivar; Selnes, Per; Grambaite, Ramune; Fladby, Tormod; Hessen, Erik (Brain and Behavior;7(9), Journal article; Peer reviewed, 2017-07-28)
      Objectives Preclinical Alzheimers disease (AD) patients may or may not show cognitive impairment on testing. AD biomarkers are central to the identification of those at low, intermediate, or high risk of later dementia ...

    • The safety attitudes questionnaire - ambulatory version: psychometric properties of the Slovenian version for the out-of-hours primary care setting 

      Klemenc-Ketis, Zalika; Maletic, Matjaz; Stropnik, Vesna; Deilkås, Ellen C Tveter; Hofoss, Dag; Bondevik, Gunnar Tchudi (BMC Health Services Research;17(1), Journal article; Peer reviewed, 2017-01-13)
      Background Several tools have been developed to measure safety attitudes of health care providers, out of which the Safety Attitudes Questionnaire (SAQ) is regarded as one of the most appropriate ones. In 2007, it was ...

    • Right and left ventricular function in hospitalized children with respiratory syncytial virus infection 

      Horter, Thorsten; Nakstad, Britt; Ashtari, Omid; Solevåg, Anne Lee (Infection and Drug Resistance;10, Journal article; Peer reviewed, 2017-11-07)
      Background: Extrapulmonary manifestations including cardiac dysfunction have been demonstrated in children with respiratory syncytial virus (RSV) infection requiring intensive care. The aim of this study was to examine ...

    • Research priorities to achieve universal access to hepatitis C prevention, management and direct-acting antiviral treatment among people who inject drugs. 

      Grebely, Jason; Bruneau, Julie; Lazarus, Jeffrey; Dalgard, Olav; Bruggmann, Philip; Treloar, Carla; Hickman, Matthew; Hellard, Margaret; Roberts, Teri; Crooks, Levinia; Midgard, Håvard; Larney, Sarah; Degenhardt, Louisa; Alho, Hannu; Byrne, Jude; Dillon, John F; Feld, Jordan J; Foster, Graham; Goldberg, David E; Lloyd, Andrew R; Reimer, Jens; Robaeys, Geert; Torrens, Marta; Wright, Nat; Maremmani, Icro; Norton, Brianna L; Litwin, Alain H; Dore, Gregory J (International Journal of Drug Policy;47, Journal article; Peer reviewed, 2017-09)
      Globally, it is estimated that 71.1 million people have chronic hepatitis C virus (HCV) infection, including an estimated 7.5 million people who have recently injected drugs (PWID). There is an additional large, but ...

    • Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer 

      Kruger, Kristi; Wik, Elisabeth; Knutsvik, Gøril; Nalwoga, Hawa; Klingen, Tor Audun; Arnes, Jarle; Chen, Ying; Mannelqvist, Monica; Dimitrakopoulou, Konstantina; Stefansson, Ingunn; Birkeland, Even; Aas, Turid; Tobin, Nicholas P; Jonassen, Inge; Bergh, Jonas; Foulkes, William D; Akslen, Lars A (Scientific Reports;7(1), Journal article; Peer reviewed, 2017-04-24)
      We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent ...