Blar i Akershus Universitetssykehus HF på forfatter "Akslen, Lars A"

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    • Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer 

      Kruger, Kristi; Wik, Elisabeth; Knutsvik, Gøril; Nalwoga, Hawa; Klingen, Tor Audun; Arnes, Jarle; Chen, Ying; Mannelqvist, Monica; Dimitrakopoulou, Konstantina; Stefansson, Ingunn; Birkeland, Even; Aas, Turid; Tobin, Nicholas P; Jonassen, Inge; Bergh, Jonas; Foulkes, William D; Akslen, Lars A (Scientific Reports;7(1), Journal article; Peer reviewed, 2017-04-24)
      We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent ...

    • Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer 

      Aziz, Sura Mohammed; Wik, Elisabeth; Knutsvik, Gøril; Klingen, Tor Audun; Chen, Ying; Davidsen, Benedicte; Aas, Hans; Aas, Turid; Akslen, Lars A (PloS one;12(2), Journal article; Peer reviewed, 2017-02-15)
      Presence of lymph node (LN) metastasis is a strong prognostic factor in breast cancer, whereas the importance of extra-nodal extension and other nodal tumor features have not yet been fully recognized. Here, we examined ...

    • Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma 

      Pilskog, Martin; Beisland, Christian; Akslen, Lars A; Bostad, Leif; Haug, Åse; Heinrich, Daniel; Hjelle, Karin Margrethe; Straume, Oddbjørn (BMC Urology;17(1), Journal article; Peer reviewed, 2017-08-31)
      Background Sunitinib has become mainstay first line treatment for patients with metastatic renal clear cell carcinoma (mRCC). Still, useful predictive markers of response are lacking and urgently needed for clinical ...

    • Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer 

      Klingen, Tor Audun; Chen, Ying; Aas, Hans; Wik, Elisabeth; Akslen, Lars A (Human Pathology;69, Journal article; Peer reviewed, 2017-11)
      Tumor-associated macrophages (TAM) resemble M2 macrophages, promote tumor invasion and show strong expression of CD163 in breast cancer. We here investigated the association between CD163-positive macrophages and vascular ...