Blar i Akershus Universitetssykehus HF på tittel
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Tailored treatment of colorectal cancer: Surgical, molecular, and genetic considerations
(Clinical Medicine Insights: Oncology;11, Journal article; Peer reviewed, 2017-02-16)Colorectal cancer (CRC) is a complex cancer disease, and approximately 40% of the surgically cured patients will experience cancer recurrence within 5 years. During recent years, research has shown that CRC treatment should ... -
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Tested and reported executive problems in children and youth epilepsy
(Brain and Behavior;8(5), Journal article; Peer reviewed, 2018-04-16)Objectives Executive problems in children and youth with epilepsy influence their ability to handle important aspects of daily life activities. The present study sought to explore factors associated with executive problems ... -
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
(Genome medicine;10(1), Journal article; Peer reviewed, 2018-11-29)Background Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its ... -
Trajectories of Depression in Late Life: A 1-Year Follow-Up Study
(Dementia and geriatric cognitive disorders;43(3-4), Journal article; Peer reviewed, 2017-04)Aims: To investigate the prognosis of depression in late life (DLL) in terms of the course of depression over 1 year and assess clinical factors related to the prognosis. Methods: We performed an observational, multicenter, ... -
Trolly dilemmas fail to predict ethical judgment in a hypothetical vaccination context
(Journal of Empirical Research on Human Research Ethics;14(1), Journal article; Peer reviewed, 2018-11-01)We investigated whether the responses of 68 ethics committee members and staff to trolley dilemmas could predict their responses to research ethics problems concerning vaccine trials. Trolley dilemmas deal with the issue ... -
Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer
(Human Pathology;69, Journal article; Peer reviewed, 2017-11)Tumor-associated macrophages (TAM) resemble M2 macrophages, promote tumor invasion and show strong expression of CD163 in breast cancer. We here investigated the association between CD163-positive macrophages and vascular ... -
Two novel connexin32 mutations cause early onset X-linked Charcot-Marie-Tooth disease
(BMC neurology;7(1), Journal article; Peer reviewed, 2007-07-09)Background X-linked Charcot-Marie Tooth (CMT) is caused by mutations in the connexin32 gene that encodes a polypeptide which is arranged in hexameric array and form gap junctions. Methods We describe two novel ... -
An update on cladribine for relapsing-remitting multiple sclerosis
(Expert Opinion on Pharmacotherapy;18(15), Journal article; Peer reviewed, 2017-09-11)INTRODUCTION: Despite recent progress, currently available therapies for relapsing remitting multiple sclerosis (MS) are only partly effective, and their use is limited by tolerability and safety issues, as well as high ... -
The usage of fasting glucose and glycated hemoglobin for the identification of unknown type 2 diabetes in high risk patients with morbid obesity
(Scandinavian journal of clinical and laboratory investigation;77(7), Journal article; Peer reviewed, 2017-07-17)Background: In spite of increased vigilance of undiagnosed type 2 diabetes (DM2), the prevalence of unknown DM2 in subjects with morbid obesity is not known. Aim: To assess the prevalence of undiagnosed DM2 and compare ... -
The Valgent4 protocol: Robust analytical and clinical validation of 11 HPV assays with genotyping on cervical samples collected in SurePath medium
(Journal of Clinical Virology;108, Journal article; Peer reviewed, 2018-09-14)Background The VALidation of HPV GENoyping Tests (VALGENT) is an international initiative designed to validate HPV assays with genotyping capability. The VALGENT4 protocol differs from previous VALGENT installments as the ... -
Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification
(Journal of The American Heart Association;6(9), Journal article; Peer reviewed, 2017-09-22)Aortic valve stenosis due to calcification of the valve leaflets is the most common valve disease in the developed world. It is the third leading cause of cardiovascular disease.1 Risk factors include male gender, smoking, ... -
Variations in patient safety climate and perceived quality of collaboration between professions in out-of-hours care
(Journal of Multidisciplinary Healthcare;10, Journal article; Peer reviewed, 2017-11-09)Purpose: To get an overview of health care workers perceptions of patient safety climates and the quality of collaboration in Slovenian out-of-hours health care (OOHC) between professional groups. Materials and methods: ... -
Vertebral Bone Mineral Density Measured by Quantitative Computed Tomography With and Without a Calibration Phantom: A Comparison Between 2 Different Software Solutions
(Journal of Clinical Densitometry;21(3), Journal article; Peer reviewed, 2018-03-27)Quantitative computed tomography (CT) can be used to quantify bone mineral density (BMD) in the spine from clinical CT scans. We aimed to determine agreement and precision of BMD measurements by 2 different methods: ... -
Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: A longitudinal multiethnic population-based study
(British Journal of Nutrition;117(7), Journal article; Peer reviewed, 2017-04-14)We investigated associations between serum 25-hydroxyvitamin D (25(OH)D) in pregnancy and birth weight and other neonatal anthropometric measures. The present study was a population-based, multiethnic cohort study of 719 ... -
What are “good outcomes” in Public mental health settings? A qualitative exploration of clients’ and therapists’ experiences
(International Journal of Mental Health Systems;11(1), Journal article; Peer reviewed, 2017-01-14)Background The mental health field sees a surge of interest in Routine Outcome Monitoring, mandated by a wish to help better those not-on-track to recovery. What constitutes positive outcomes for these patients is not ...