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dc.contributor.authorAdobor, Raphael Dziwornuen_US
dc.contributor.authorJoranger, Pålen_US
dc.contributor.authorSteen, Haralden_US
dc.contributor.authorNavrud, Ståleen_US
dc.contributor.authorBrox, Jens Ivaren_US
dc.date.accessioned2015-02-10T09:38:13Z
dc.date.available2015-02-10T09:38:13Z
dc.date.issued2014en_US
dc.identifier.citationAdobor, R.D., Joranger, P., Steen, H., Navrud, S. & Brox, J.I. (2014). A health economic evaluation of screening and treatment in patients with adolescent idiopathic scoliosis. Scoliosis, 9(21). doi: 10.1186/s13013-014-0021-8en_US
dc.identifier.issn1748-7161en_US
dc.identifier.otherFRIDAID 1197130en_US
dc.identifier.urihttps://hdl.handle.net/10642/2367
dc.description.abstractSummary of background data Adolescent idiopathic scoliosis can progress and affect the health related quality of life of the patients. Research shows that screening is effective in early detection, which allows for bracing and reduced surgical rates, and may save costs, but is still controversial from a health economic perspective. Study design Model based cost minimisation analysis using hospital’s costs, administrative data, and market prices to estimate costs in screening, bracing and surgical treatment. Uncertainty was characterised by deterministic and probabilistic sensitivity analyses. Time horizon was 6 years from first screening at 11 years of age.Objective To compare estimated costs in screening and non-screening scenarios (reduced treatment rates of 90%, 80%, 70% of screening, and non-screening Norway 2012). Methods Data was based on screening and treatment costs in primary health care and in hospital care settings. Participants were 4000, 12-year old children screened in Norway, 115190 children screened in Hong Kong and 112 children treated for scoliosis in Norway in 2012. We assumed equivalent outcome of health related quality of life, and compared only relative costs in screening and non-screening settings. Incremental cost was defined as positive when a non-screening scenario was more expensive relative to screening. Results Screening per child was € 8.4 (95% CrI 6.6 to10.6), € 10350 (8690 to 12180) per patient braced, and € 45880 (39040 to 55400) per child operated. Incremental cost per child in nonscreening scenario of 90% treatment rate was € 13.3 (1 to 27), increasing from € 1.3 (−8 to 11) to € 27.6 (14 to 44) as surgical rates relative to bracing increased from 40% to 80%. For the 80% treatment rate non-screening scenario, incremental cost was € 5.5 (−6 to 18) when screening all, and € 11.3 (2 to 22) when screening girls only. For the non-screening Norwegian scenario, incremental cost per child was € -0.1(−14 to 16). Bracing and surgery were the main cost drivers and contributed most to uncertainty. Conclusions With the assumptions applied in the present study, screening is cost saving when performed in girls only, and when it leads to reduced treatment rates. Cost of surgery was dominating in non-screening whilst cost of bracing was dominating in screening. The economic gain of screening increases when it leads to higher rates of bracing and reduced surgical rates.en_US
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofseriesScoliosis;9(21)en_US
dc.subjectCost minimisation analysisen_US
dc.subjectScoliosis screeningen_US
dc.subjectScoliosis treatmenten_US
dc.subjectQuality of lifeen_US
dc.subjectHealthen_US
dc.titleA health economic evaluation of screening and treatment in patients with adolescent idiopathic scoliosisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.version© 2015 Adobor et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.identifier.doihttp://dx.doi.org/10.1186/s13013-014-0021-8


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