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Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD

Dervola, Kine S; Roberg, Bjørg Å; Wøien, Grete; Bogen, Inger Lise; Sandvik, Torbjørn H; Sagvolden, Terje; Drevon, Christian A; Johansen, Espen Borgå; Walaas, Sven Ivar
Journal article, Peer reviewed
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URI
https://hdl.handle.net/10642/1351
Date
2012
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  • HV - Department of Behavioural Sciences [208]
Original version
Dervola, K.S., Roberg, B.Å., Wøien, G., Bogen, I.L., Sandvik, T.H., Sagvolden, T., ... Walaas, S.I. (2012). Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behavior and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD. Behavioral and Brain Functions, 8(56),   http://dx.doi.org/10.1186/1744-9081-8-56
http://www.behavioralandbrainfunctions.com/content/8/1/56
Abstract
Previous reports suggest that omega-3 (n-3) polyunsaturated fatty acids (PUFA) supplements

may reduce ADHD-like behaviour. Our aim was to investigate potential effects of n-3 PUFA

supplementation in an animal model of ADHD.

Methods

We used spontaneously hypertensive rats (SHR). SHR dams were given n-3 PUFA (EPA and

DHA)-enriched feed (n-6/n-3 of 1:2.7) during pregnancy, with their offspring continuing on

this diet until sacrificed. The SHR controls and Wistar Kyoto (WKY) control rats were given

control-feed (n-6/n-3 of 7:1). During postnatal days (PND) 25–50, offspring were tested for

reinforcement-dependent attention, impulsivity and hyperactivity as well as spontaneous

locomotion. The animals were then sacrificed at PND 55–60 and their neostriata were

analysed for monoamine and amino acid neurotransmitters with high performance liquid

chromatography.

Results

n-3 PUFA-feeding improved reinforcement-induced attention in males but not in female

SHRs. Analysis of neostriata from the same animals showed significantly enhanced

dopamine and serotonin turnover ratios in the male SHRs, whereas female SHRs showed no

change, except for an intermediate increase in serotonin catabolism. In contrast, both male

and female SHRs showed n-3 PUFA-induced reduction in non-reinforced spontaneous

locomotion, and sex-independent changes in glycine levels and glutamate turnover.

Conclusions

Feeding n-3 PUFAs to the ADHD model rats induced sex-specific changes in reinforcementmotivated

behaviour and a sex-independent change in non-reinforcement-associated

behaviour, which correlated with changes in presynaptic striatal monoamine and amino acid

signalling, respectively. Thus, dietary n-3 PUFAs may partly ameliorate ADHD-like

behaviour by reinforcement-induced mechanisms in males and partly via reinforcementinsensitive

mechanisms in both sexes
Publisher
BioMed Central
Series
Behavioral and Brain Functions;8(56)

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