Browsing ODA Open Digital Archive by Author "Wik, Elisabeth"
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Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer
Kruger, Kristi; Wik, Elisabeth; Knutsvik, Gøril; Nalwoga, Hawa; Klingen, Tor Audun; Arnes, Jarle; Chen, Ying; Mannelqvist, Monica; Dimitrakopoulou, Konstantina; Stefansson, Ingunn; Birkeland, Even; Aas, Turid; Tobin, Nicholas P; Jonassen, Inge; Bergh, Jonas; Foulkes, William D; Akslen, Lars A (Scientific Reports;7(1), Journal article; Peer reviewed, 2017-04-24)We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent ... -
Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer
Aziz, Sura Mohammed; Wik, Elisabeth; Knutsvik, Gøril; Klingen, Tor Audun; Chen, Ying; Davidsen, Benedicte; Aas, Hans; Aas, Turid; Akslen, Lars A (PloS one;12(2), Journal article; Peer reviewed, 2017-02-15)Presence of lymph node (LN) metastasis is a strong prognostic factor in breast cancer, whereas the importance of extra-nodal extension and other nodal tumor features have not yet been fully recognized. Here, we examined ... -
Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer
Klingen, Tor Audun; Chen, Ying; Aas, Hans; Wik, Elisabeth; Akslen, Lars A (Human Pathology;69, Journal article; Peer reviewed, 2017-11)Tumor-associated macrophages (TAM) resemble M2 macrophages, promote tumor invasion and show strong expression of CD163 in breast cancer. We here investigated the association between CD163-positive macrophages and vascular ...