• Artificial intelligence in dry eye disease 

      Storås, Andrea Marheim; Strumke, Inga; Riegler, Michael Alexander; Grauslund, Jakob; Hammer, Hugo Lewi; Yazidi, Anis; Halvorsen, Pål; Gundersen, Kjell Gunnar; Utheim, Tor Paaske; Jackson, Catherine Joan (The ocular surface;Volume 23, January 2022, Peer reviewed; Journal article, 2021-12-01)
      Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. ...
    • The association between visual display terminal use and dry eye: a review 

      Fjærvoll, Haakon Kristoffer Olsen; Fjærvoll, Ketil Andreas Olsen; Magnø, Morten Scherven; Moschowits, Emily; Vehof, Jelle; Dartt, Darlene A.; Utheim, Tor Paaske (Acta Ophthalmologica;, Peer reviewed; Journal article, 2021-10-25)
      Background. Dry eye disease (DED) is a multifactorial disease of the tear film and ocular surface. It causes ocular symptoms, reduced quality of life and a considerable economic burden on society. Prolonged use of visual ...
    • Change in Ocular Surface Staining during Eyelid Warming Is Related to Tear Cytokine Levels 

      Landsend, Erlend Christoffer Sommer; Olafsson, Jonatan; Lai, Xiaoran; Aass, Hans Christian Dalsbotten; Utheim, Tor Paaske (Journal of ophthalmology;Volume 2022, Article ID 5103231, Peer reviewed; Journal article, 2022-08-03)
      Purpose. To investigate the changes in the tear cytokine profile of patients with meibomian gland dysfunction (MGD) treated with eyelid warming and to correlate these changes with clinical parameters for dry eye disease ...
    • In-office thermal systems for the treatment of dry eye disease 

      Beining, Marie Wangen; Magnø, Morten Scherven; Moschowits, Emily; Olafsson, Jonatan; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Survey of ophthalmology;Volume 67, Issue 5, September–October 2022, Peer reviewed; Journal article, 2022-08-12)
      Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dysfunction, a major cause of dry eye, is characterized by chronic glandular inflammation, ...
    • Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study 

      Tashbayev, Behzod; Garen, Torhild Oddveig; Palm, Øyvind; Chen, Xiangjun; Herlofson, Bente Brokstad; Young Vik, Alix Rosslyn; Hove, Lene Hystad; Rykke, Morten; Singh, Preet Bano; Aqrawi, Lara Adnan; Utheim, Øygunn Aass; Utheim, Tor Paaske; Jensen, Janicke Cecilie Liaaen (Scientific Reports;10, Article number: 2063 (2020), Journal article; Peer reviewed, 2020-02-07)
      Understanding the impact of the disease on quality of life is crucial in patient management. In this cross-sectional study, general and oral health-related quality of life questionnaires, and thorough examinations of oral ...
    • Perturbation of astroglial Slc38 glutamine transporters by NH4 + contributes to neurophysiologic manifestations in acute liver failure 

      Hamdani, El Hassan; Popek, Mariusz; Frontczak-Baniewicz, Małgorzata; Utheim, Tor Paaske; Albrecht, Jan; Zielińska, Magdalena; Chaudhry, Farrukh Abbas (Wiley Open Access;Volume 35, Issue 7, Peer reviewed; Journal article, 2021-06-24)
      Ammonia is considered the main pathogenic toxin in hepatic encephalopathy (HE). However, the molecular mechanisms involved have been disputed. As altered glutamatergic and GABAergic neurotransmission has been reported in ...
    • Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease 

      Fjærvoll, Ketil Andreas Olsen; Fjærvoll, Haakon Kristoffer Olsen; Magnø, Morten Scherven; Tellefsen Nøland, Sara Julie Maria; Dartt, Darlene Ann; Vehof, Jelle; Utheim, Tor Paaske (Acta Ophthalmologica;, Peer reviewed; Journal article, 2022-04-19)
      Background: Visual display terminal (VDT) use is a key risk factor for dry eye disease (DED). Visual display terminal (VDT) use reduces the blink rate and increases the number of incomplete blinks. However, the exact ...
    • Stem cell function is conserved during shortterm storage of cultured epidermal cell sheets at 12°C 

      Ringstad, Håkon; Reppe, Sjur; Schøyen, Tine Hiorth; Tønseth, Kim Alexander; Utheim, Tor Paaske; Jackson, Catherine (PLOS ONE;15 (5): e0232270, Journal article; Peer reviewed, 2020-05-20)
      Transplantation of cultured epidermal cell sheets (CES) can be life-saving for patients with large area burns. CES have also been successfully used to regenerate eye and urethral epithelia in animal models. Short-term ...
    • Tear metabolomics in dry eye disease: A review 

      Yazdani, Mazyar; Elgstøen, Katja B. Prestø; Rootwelt, Helge; Shahdafar, Aboulghassem; Utheim, Øygunn Aass; Utheim, Tor Paaske (International Journal of Molecular Sciences;Volume 20, Issue 15, Journal article; Peer reviewed, 2019-08-01)
      Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear film. It is considered one of the most common ocular conditions leading patients to seek ...
    • The therapeutic benefits of nanoencapsulation in drug delivery to the anterior segment of the eye: A systematic review 

      Bandhari, Madhavi; Nguyen, Sanko; Yazdani, Mazyar; Utheim, Tor Paaske; Hagesæther, Ellen (Frontiers in Pharmacology;May 2022 | Volume 13 | Article 903519, Peer reviewed; Journal article, 2022-05-13)
      Background: Although numerous nanoparticle formulations have been developed for ocular administration, concerns are being raised about a possible mismatch between potential promises made by the field of nanoparticle research ...
    • Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease 

      Tashbayev, Behzod; Utheim, Tor Paaske; Utheim, Øygunn Aass; Ræder, Sten; Jensen, Janicke Cecilie Liaaen; Yazdani, Mazyar; Lagali, Neil Satish; Vitelli, Valeria; Dartt, Darlene Ann; Chen, Xiangjun (Scientific Reports;10, Article number: 5542 (2020), Journal article; Peer reviewed, 2020-03-26)
      The prevalence of dry eye disease is high worldwide and poses a great burden on patients’ daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is ...