Browsing ODA Open Digital Archive by Author "Utheim, Tor Paaske"

Now showing items 1-20 of 24

    • Artificial intelligence in dry eye disease 

      Storås, Andrea Marheim; Strumke, Inga; Riegler, Michael Alexander; Grauslund, Jakob; Hammer, Hugo Lewi; Yazidi, Anis; Halvorsen, Pål; Gundersen, Kjell Gunnar; Utheim, Tor Paaske; Jackson, Catherine Joan (The ocular surface;Volume 23, January 2022, Peer reviewed; Journal article, 2021-12-01)
      Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. ...

    • The association between visual display terminal use and dry eye: a review 

      Fjærvoll, Haakon Kristoffer Olsen; Fjærvoll, Ketil Andreas Olsen; Magnø, Morten Scherven; Moschowits, Emily; Vehof, Jelle; Dartt, Darlene A.; Utheim, Tor Paaske (Acta Ophthalmologica;, Peer reviewed; Journal article, 2021-10-25)
      Background. Dry eye disease (DED) is a multifactorial disease of the tear film and ocular surface. It causes ocular symptoms, reduced quality of life and a considerable economic burden on society. Prolonged use of visual ...

    • Beyond the Black Box: Transparent Machine Learning Systems for Medical Applications 

      Storås, Andrea Theomine Marheim (OsloMet Avhandling;2024 24/25, Doctoral thesis, 2024)
      Artificial intelligence and machine learning (ML) have become a part of our everyday lives. The advancement of such technology affects the society by assisting us in several tasks. Healthcare and medicine are some domains ...

    • Cataract Surgery and Dry Eye Disease - Prevalence, Effects of Preservative-Free Eyedrops and Artificial Tears in Pre-and Postoperative Care 

      Jensen, Per Graae (OsloMet Avhandling;2025 nr. 20, Doctoral thesis, 2025)
      Modern cataract surgery, utilizing advanced lens technology, has evolved into a refractive procedure with a strong emphasis on refractive precision. Achieving this precision requires thorough preoperative assessment and ...

    • Change in Ocular Surface Staining during Eyelid Warming Is Related to Tear Cytokine Levels 

      Landsend, Erlend Christoffer Sommer; Olafsson, Jonatan; Lai, Xiaoran; Aass, Hans Christian Dalsbotten; Utheim, Tor Paaske (Journal of ophthalmology;Volume 2022, Article ID 5103231, Peer reviewed; Journal article, 2022-08-03)
      Purpose. To investigate the changes in the tear cytokine profile of patients with meibomian gland dysfunction (MGD) treated with eyelid warming and to correlate these changes with clinical parameters for dry eye disease ...

    • A Complete Globe Dislocation without Orbital Wall Fracture 

      Tashbayev, Behzod; Utheim, Tor Paaske; Tsigkris, Panagiotis; Shanks, Guy (Case Reports in Ophthalmology;, Peer reviewed; Journal article, 2024)
      Introduction: The complete globe dislocation is a rare type of trauma in clinical practice of ophthalmologists. Case Presentation: In this report, we present a case of complete globe dislocation with optic nerve avulsion ...

    • Culture- and non-culture-based approaches reveal unique features of the ocular microbiome in dry eye patients 

      Naqvi, Maria; Fineide, Fredrik; Utheim, Tor Paaske; Charnock, Colin (Peer reviewed; Journal article, 2024)
      Purpose: The purpose of this study was to investigate the ocular microbiome in individuals with dry eye disease and to identify features of their ocular microbiome of possible health and diagnostic significance. Methods: ...

    • Identifying Important Proteins in Meibomian Gland Dysfunction with Explainable Artificial Intelligence 

      Storås, Andrea; Magnø, Morten Schjerven; Fineide, Fredrik; Thiede, Bernd; Chen, Xiangjun; Strumke, Inga; Halvorsen, Pål; Utheim, Tor Paaske; Riegler, Michael Alexander (Peer reviewed; Journal article, 2023)
      Meibomian gland dysfunction is the most common cause of dry eye disease and leads to significantly reduced quality of life and social burdens. Because meibomian gland dysfunction results in impaired function of the tear ...

    • The Impact of Dry Eye Disease before and after cataract surgery 

      Nilsen, Christian (OsloMet Avhandling;2025 nr. 23, Doctoral thesis, 2025)
      The outcomes of modern cataract surgery are generally very good. About 80% of patients achieve the intended refractive precision within 0.5 diopters. Only a few patients experience refractive errors of more than 0.75 or ...

    • In-office thermal systems for the treatment of dry eye disease 

      Beining, Marie Wangen; Magnø, Morten Scherven; Moschowits, Emily; Olafsson, Jonatan; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Survey of ophthalmology;Volume 67, Issue 5, September–October 2022, Peer reviewed; Journal article, 2022-08-12)
      Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dysfunction, a major cause of dry eye, is characterized by chronic glandular inflammation, ...

    • Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study 

      Tashbayev, Behzod; Garen, Torhild Oddveig; Palm, Øyvind; Chen, Xiangjun; Herlofson, Bente Brokstad; Young Vik, Alix Rosslyn; Hove, Lene Hystad; Rykke, Morten; Singh, Preet Bano; Aqrawi, Lara Adnan; Utheim, Øygunn Aass; Utheim, Tor Paaske; Jensen, Janicke Cecilie Liaaen (Scientific Reports;10, Article number: 2063 (2020), Journal article; Peer reviewed, 2020-02-07)
      Understanding the impact of the disease on quality of life is crucial in patient management. In this cross-sectional study, general and oral health-related quality of life questionnaires, and thorough examinations of oral ...

    • Perturbation of astroglial Slc38 glutamine transporters by NH4 + contributes to neurophysiologic manifestations in acute liver failure 

      Hamdani, El Hassan; Popek, Mariusz; Frontczak-Baniewicz, Małgorzata; Utheim, Tor Paaske; Albrecht, Jan; Zielińska, Magdalena; Chaudhry, Farrukh Abbas (Wiley Open Access;Volume 35, Issue 7, Peer reviewed; Journal article, 2021-06-24)
      Ammonia is considered the main pathogenic toxin in hepatic encephalopathy (HE). However, the molecular mechanisms involved have been disputed. As altered glutamatergic and GABAergic neurotransmission has been reported in ...

    • A Preservative-Free Approach – Effects on Dry Eye Signs and Symptoms After Cataract Surgery 

      Jensen, Per Graae; Nilsen, Christian; Gundersen, Morten; Gundersen, Kjell Gunnar; Potvin, Rick; Gazerani, Parisa; Chen, Xiangjun; Utheim, Tor Paaske; Utheim, Øygunn Aass (Peer reviewed; Journal article, 2024)
      Purpose: To compare the effect of treatment with preservative-free dexamethasone, NSAIDs and trehalose/hyaluronic acid eye drops with the preservative benzalkonium chloride containing dexamethasone and NSAIDs after cataract ...

    • Prevalence of Dry Eye Disease Among Individuals Scheduled for Cataract Surgery in a Norwegian Cataract Clinic 

      Graae Jensen, Per; Gundersen, Morten; Nilsen, Christian; Gundersen, Kjell Gunnar; Potvin, Rick; Gazerani, Parisa; Chen, Xiangjun; Utheim, Tor Paaske; Utheim, Øygunn Aass (Clinical Ophthalmology;, Peer reviewed; Journal article, 2023)
      Purpose: To determine the prevalence of dry eye disease (DED) in patients scheduled for cataract surgery in a Norwegian eye clinic. Patients and Methods: 218 patients scheduled for cataract surgery were examined for DED ...

    • Response predictors of a topical corticosteroid-based regimen for dry eyes: A real-life study 

      Utheim, Tor Paaske; Chen, Xiangjun; Fineide, Fredrik; Steinkjer, Tore; Heegaard, Steffen; Kolko, Miriam; Dartt, Darlene A.; Khan, Ayyad Ahmad Zartasht (Peer reviewed; Journal article, 2024)
      Purpose: To examine the effectiveness and identify clinical response predictors of a short corticosteroid-based regimen consisting of topical preservative-free 0.1% dexamethasone (Monopex®, Théa Laboratories) in conjunction ...

    • Review of Hydroxypropyl Methylcellulose in Artificial Tears for the Treatment of Dry Eye Disease 

      Mysen, O. Martin B.; Hynnekleiv, Leif; Magnø, Morten Schjerven; Vehof, Jelle; Utheim, Tor Paaske (Peer reviewed; Journal article, 2024)
      Dry eye disease (DED) is a highly prevalent condition, resulting in reduced quality of life, lower participation in social life and impaired work efficiency. Hydroxypropyl methylcellulose (HPMC) is a cellulose-based ...

    • Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease 

      Fjærvoll, Ketil Andreas Olsen; Fjærvoll, Haakon Kristoffer Olsen; Magnø, Morten Scherven; Tellefsen Nøland, Sara Julie Maria; Dartt, Darlene Ann; Vehof, Jelle; Utheim, Tor Paaske (Acta Ophthalmologica;, Peer reviewed; Journal article, 2022-04-19)
      Background: Visual display terminal (VDT) use is a key risk factor for dry eye disease (DED). Visual display terminal (VDT) use reduces the blink rate and increases the number of incomplete blinks. However, the exact ...

    • Stem cell function is conserved during shortterm storage of cultured epidermal cell sheets at 12°C 

      Ringstad, Håkon; Reppe, Sjur; Schøyen, Tine Hiorth; Tønseth, Kim Alexander; Utheim, Tor Paaske; Jackson, Catherine (PLOS ONE;15 (5): e0232270, Journal article; Peer reviewed, 2020-05-20)
      Transplantation of cultured epidermal cell sheets (CES) can be life-saving for patients with large area burns. CES have also been successfully used to regenerate eye and urethral epithelia in animal models. Short-term ...

    • Tear metabolomics in dry eye disease: A review 

      Yazdani, Mazyar; Elgstøen, Katja B. Prestø; Rootwelt, Helge; Shahdafar, Aboulghassem; Utheim, Øygunn Aass; Utheim, Tor Paaske (International Journal of Molecular Sciences;Volume 20, Issue 15, Journal article; Peer reviewed, 2019-08-01)
      Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear film. It is considered one of the most common ocular conditions leading patients to seek ...

    • The therapeutic benefits of nanoencapsulation in drug delivery to the anterior segment of the eye: A systematic review 

      Bandhari, Madhavi; Nguyen, Sanko; Yazdani, Mazyar; Utheim, Tor Paaske; Hagesæther, Ellen (Frontiers in Pharmacology;May 2022 | Volume 13 | Article 903519, Peer reviewed; Journal article, 2022-05-13)
      Background: Although numerous nanoparticle formulations have been developed for ocular administration, concerns are being raised about a possible mismatch between potential promises made by the field of nanoparticle research ...