• Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome 

      Bucher-Johannessen, Cecilie; Page, Christian Magnus; Haugen, Trine B.; Wojewodzic, Marcin; Fosså, Sophie Dorothea; Grotmol, Tom; Haugnes, Hege Sagstuen; Rounge, Trine Ballestad (Clinical Epigenetics;11, Article number: 179 (2019), Journal article; Peer reviewed, 2019-12-03)
      Background: Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. In this epigenomewide ...
    • The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants 

      Kværner, Ane Sørlie; Birkeland, Einar Elvbakken; Bucher-Johannessen, Cecilie; Vinberg, Elina; Nordby, Jan Inge; Kangas, Harri; Bemanian, Vahid; Ellonen, Pekka; Botteri, Edoardo; Natvig, Erik; Rognes, Torbjørn; Hovig, Eivind; Lyle, Robert; Ambur, Ole Herman; de Vos, Willem M.; Bultman, Scott J; Hjartåker, Anette; Landberg, Rikard; Song, Mingyang; Blix, Hege Salvesen; Ursin, Giske; Randel, Kristin Ranheim; de Lange, Thomas; Hoff, Geir; Holme, Øyvind; Berstad, Paula; Rounge, Trine Ballestad (BMC Cancer;21, Article number: 930 (2021), Peer reviewed; Journal article, 2021-08-18)
      Background: Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness as primary ...
    • HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization 

      Meisal, Roger; Rounge, Trine Ballestad; Christiansen, Irene Kraus; Eieland, Alexander Kirkeby; Worren, Merete Molton; Molden, Tor; Kommedal, Øyvind; Hovig, Eivind; Leegaard, Truls Michael; Ambur, Ole Herman (Journal article; Peer reviewed, 2017)
      Sensitive and specific genotyping of human papillomaviruses (HPVs) is important for population-based surveillance of carcinogenic HPV types and for monitoring vaccine effectiveness. Here we compare HPV genotyping by Next ...
    • HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples 

      Lagström, Sonja; Løvstad, Alexander H; Umu, Sinan Uğur; Ambur, Ole Herman; Nygård, Mari; Rounge, Trine Ballestad; Christiansen, Irene Kraus (Tumour Virus Research;Volume 12, December 2021, 200221, Peer reviewed; Journal article, 2021-07-14)
      Human papillomavirus (HPV) 16 and 18 are the most predominant types in cervical cancer. Only a small fraction of HPV infections progress to cancer, indicating that additional factors and genomic events contribute to the ...
    • HPV16 whole genome minority variants in persistent infections from young Dutch women 

      Lagström, Sonja; van der Weele, Pascal; Rounge, Trine Ballestad; Christiansen, Irene Kraus; King, Audrey; Ambur, Ole Herman (Journal of Clinical Virology;Volume 119, October 2019, Journal article; Peer reviewed, 2019-08-09)
      Background: Chronic infections by one of the oncogenic human papillomaviruses (HPVs) are responsible for near 5% of the global cancer burden and HPV16 is the type most often found in cancers. HPV genomes displayunexpected ...
    • Intra-host sequence variability in human papillomavirus 

      Mandishora, Racheal Shamiso Dube; Gjøtterud, Kristina Stormo; Lagström, Sonja; Stray-Pedersen, Babill; Duri, Kerina; Chin'ombe, Nyasha; Nygård, Mari; Christiansen, Irene Kraus; Ambur, Ole Herman; Chirenje, Mike Zvavahera; Rounge, Trine Ballestad (Papillomavirus Research. The Journal of HPV and other Small DNA Tumor Viruses;Volume 5, June 2018, Journal article; Peer reviewed, 2018-04-30)
      Human papillomaviruses (HPVs) co-evolve slowly with the human host and each HPV genotype displays epithelial tropisms. We assessed the evolution of intra HPV genotype variants within samples, and their association to ...
    • Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs 

      Rounge, Trine Ballestad; Furu, Kari; Skotheim, Rolf Inge; Haugen, Trine B.; Grotmol, Tom; Enerly, Espen (Journal article; Peer reviewed, 2015)
      Background Small non-coding RNAs play essential roles in gene regulation, however, the interplay between RNA groups, their expression levels and deregulations in tumorigenesis requires additional exploration. In particular, ...
    • Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping 

      Mandishora, Racheal S. Dube; Rounge, Trine Ballestad; Fitzpatrick, Megan; Christiansen, Hanne Irene Kraus; Ambur, Ole Herman; Lagström, Sonja; Stray-Pedersen, Babill; Tommasino, Massimo; Palefsky, Joel; Chirenje, Zvavahera M. (PLOS ONE;16 (4): e0250426, Peer reviewed; Journal article, 2021-04-26)
      Background & aim: Women with HIV/HPV coinfection and cervical lesions are at increased risk of developing HPV related anal cancer. Self-collection of anal swabs may facilitate HPV molecular testing in anal cancer screening, ...
    • Serum RNA profiling in the 10-year period prior to diagnosis of testicular germ cell tumour 

      Burton, Joshua; Umu, Sinan Uğur; Langseth, Hilde; Grotmol, Tom; Grimsrud, Tom Kristian; Haugen, Trine B.; Rounge, Trine Ballestad (Frontiers in Oncology;volume 10, Peer reviewed; Journal article, 2020-10-28)
      Although testicular germ cell tumor (TGCT) overall is highly curable, patients may experience late effects after treatment. An increased understanding of the mechanisms behind the development of TGCT may pave the way for ...
    • TaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration 

      Lagström, Sonja; Umu, Sinan Uğur; Lepistö, Maija; Ellonen, Pekka; Meisal, Roger; Christiansen, Irene Kraus; Ambur, Ole Herman; Rounge, Trine Ballestad (Scientific Reports;9, Article number: 524 (2019), Journal article; Peer reviewed, 2018-11-26)
      HPV genomic variability and chromosomal integration are important in the HPV-induced carcinogenic process. To uncover these genomic events in an HPV infection, we have developed an innovative and cost-effective sequencing ...