• Assessment and manipulation of the computational capacity of in vitro neuronal networks through criticality in neuronal avalanches 

      Heiney, Kristine; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (2019 IEEE Symposium Series on Computational Intelligence (SSCI);, Chapter; Conference object; Peer reviewed, 2020)
      In this work, we report the preliminary analysis of the electrophysiological behavior of in vitro neuronal networks to identify when the networks are in a critical state based on the size distribution of network-wide ...
    • Criticality as a measure of developing proteinopathy in engineered human neural networks 

      Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (bioRxiv;, Journal article, 2020-05-04)
      A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of alpha-synuclein proteins aggregate and accumulate in hallmark ...
    • Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks 

      Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (American Journal of Physiology - Cell Physiology;, Peer reviewed; Journal article, 2021-06-18)
      A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of alpha-synuclein proteins accumulate in hallmark pathological ...
    • Evolving spiking neuron cellular automata and networks to emulate in vitro neuronal activity 

      Jensen Farner, Jørgen; Weydahl, Håkon; Jahren, Ruben; Huse Ramstad, Ola; Nichele, Stefano; Heiney, Kristine Anne (IEEE Symposium Series on Computational Intelligence (SSCI);2021 IEEE Symposium Series on Computational Intelligence (SSCI), Chapter; Peer reviewed; Conference object, 2021-01-24)
      Neuro-inspired models and systems have great potential for applications in unconventional computing. Often, the mechanisms of biological neurons are modeled or mimicked in simulated or physical systems in an attempt to ...
    • Hallmarks of Criticality in Neuronal Networks Depend on Cell Type and the Temporal Resolution of Neuronal Avalanches 

      Heiney, Kristine; Valderhaug, Vibeke Devold; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (International Journal of Unconventional Computing;Volume 16, Number 4 (2021), Peer reviewed; Journal article, 2021)
      The human brain has a remarkable capacity for computation, and it has been theorized that this capacity arises from the brain self-organizing into the critical state, a dynamical state poised between ordered and dis- ordered ...
    • Method to Obtain Neuromorphic Reservoir Networks from Images of in Vitro Cortical Networks 

      Mello, Gustavo; Pontes-Filho, Sidney; Sandvig, Ioanna; Valderhaug, Vibeke Devold; Zouganeli, Evi; Huse Ramstad, Ola; Sandvig, Axel; Nichele, Stefano (IEEE Symposium Series on Computational Intelligence (SSCI);, Chapter; Peer reviewed, 2020-02-20)
      In the brain, the structure of a network of neurons defines how these neurons implement the computations that underlie the mind and the behavior of animals and humans. Provided that we can describe the network of neurons ...
    • Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networks 

      Valderhaug, Vibeke Devold; Huse Ramstad, Ola; van de Wijdeven, Rosanne Francisca; Heiney, Kristine; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (bioRxiv;, Journal article, 2020-05-02)
      Mutations in the LRRK2 gene have been widely linked to Parkinson ́s disease. The G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been ...
    • Towards Making a Cyborg: A Closed-Loop Reservoir-Neuro System 

      Aaser, Peter; Knudsen, Martinius; Huse Ramstad, Ola; van de Wijdeven, Rosanne; Nichele, Stefano; Sandvig, Ioanna; Tufte, Gunnar; Bauer, Ulrich Stefan; Halaas, Øyvind; Hendseth, Sverre; Sandvig, Axel; Valderhaug, Vibeke Devold (Chapter; Peer reviewed, 2017)
      The human brain is a remarkable computing machine, i.e. vastly parallel, self-organizing, robust, and energy efficient. To gain a better understanding into how the brain works, a cyborg (cybernetic organism, a combination ...