Browsing ODA Open Digital Archive by Author "Hole, Kristine"
Now showing items 1-5 of 5
-
Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals
Tveit, Kristine; Hermann, Monica; Nilsen, Roy Miodini; Wallerstedt, Susanna M.; Rongve, Arvid; Molden, Espen; Hole, Kristine (European Journal of Clinical Pharmacology;, Peer reviewed; Journal article, 2024)Purpose: The aim of this study was to examine the age of onset for increased dose-adjusted serum concentrations (C/D ratio) of common antidepressant drugs and to explore the potential association with sex and CYP2C19/CYP2D6 ... -
Betydning av CYP-genotype for farmakokinetisk variasjon av fluoksetin – en retrospektiv observasjonsstudie
Nordby, Karoline Linnea (Master thesis, 2024)Bakgrunn: Fluoksetin er en selektiv serotoninreopptakshemmer som metaboliseres primært av CYP2D6, med mindre bidrag fra CYP2C9, CYP2C19 og CYP3A5. Fluoksetin metaboliseres hovedsakelig til norfluoksetin, som har lignende ... -
Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine; Johnson, Line Kristin; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Åsberg, Anders; Molden, Espen; Robertsen, Ida (European Journal of Clinical Pharmacology;Volume 78, issue 8, Peer reviewed; Journal article, 2022-06-01)Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol (4βOHC) is a promising ... -
Effect of CYP2D6 genotype on duloxetine serum concentration
Hole, Kristine; Gangsø, Sofie; Jensstuen, Åse Tonette; Ormøy, Hanne Holte; Paulsen, Maren; Molden, Espen; Haslemo, Tore (Peer reviewed; Journal article, 2023)Duloxetine is metabolized by cytochrome P450 (CYP)1A2 and CYP2D6. The aim of this study was to investigate the effect of the CYP2D6 genotype on duloxetine serum concentration adjusting for age and sex. Patients were included ... -
Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients
Faraj, Pari; Størset, Elisabet; Hole, Kristine; Smith, Godfrey L; Molden, Espen; Dietrichs, Erik Sveberg (Peer reviewed; Journal article, 2023)Background For a decade, patients have been advised against using high citalopram- and escitalopram-doses due to risk for ventricular arrhythmia and cardiac arrest. Still, these drugs are widely used to treat depression ...