Browsing ODA Open Digital Archive by Author "Hellum, Christian"
Now showing items 1-14 of 14
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Adjacent Disc Degeneration After Lumbar Total Disc Replacement or Non-operative Treatment: A Randomized Study With Eight-year Follow-up.
Furunes, Håvard; Hellum, Christian; Espeland, Ansgar; Brox, Jens Ivar; Småstuen, Milada C; Berg, Linda; Storheim, Kjersti (Spine;Volume 43, Number 24, Journal article; Journal article; Peer reviewed, 2018-12-01)Study design: Randomized controlled multicenter trial with eight-year follow-up. Objective; To assess the long-term development of adjacent disc degeneration (ADD) after lumbar total disc replacement (TDR) or non-operative ... -
Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - Secondary analyses of a randomised, placebo-controlled trial (the AIM study)
Bråten, Lars Christian Haugli; Grøvle, Lars; Espeland, Ansgar; Pripp, Are Hugo; Grotle, Margreth; Hellum, Christian; Haugen, Anne Julsrud; Froholdt, Anne; Rolfsen, Mads Peder; Nygaard, Øystein Petter; Lutro, Olav; Kristoffersen, Per Martin; Anke, Audny; Schistad, Ellina Iordanova; Skouen, Jan Sture; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (BMC Musculoskeletal Disorders;21, Article number: 458 (2020), Journal article; Peer reviewed, 2020-07-13)Background: Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real ... -
Comparable increases in dural sac area after three different posterior decompression techniques for lumbar spinal stenosis: radiological results from a randomized controlled trial in the NORDSTEN study
Hermansen, Erland; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Aaen, Jørn Ståle; Banitalebi, Hasan; Anvar, Masoud D; Rekeland, Frode; Brox, Jens Ivar; Franssen, Eric; Weber, Clemens; Solberg, Tore; Haug, Knut Jørgen; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari (European spine journal;, Journal article; Peer reviewed, 2020-06-18)Purpose: To investigate changes in dural sac area after three different posterior decompression techniques in patients undergoing surgery for lumbar spinal stenosis. Summary of background data: Decompression of the ... -
Comparison of the SF6D, the EQ5D, and the oswestry disability index in patients with chronic low back pain and degenerative disc disease
Johnsen, Lars Gunnar; Hellum, Christian; Nygaard, Øystein Petter; Storheim, Kjersti; Brox, Jens Ivar; Rossvoll, Ivar; Leivseth, Gunnar; Grotle, Margreth (BMC musculoskeletal disorders;14(1), Journal article; Peer reviewed, 2013-04-26)Background The need for cost effectiveness analyses in randomized controlled trials that compare treatment options is increasing. The selection of the optimal utility measure is important, and a central question is ... -
Decompression alone versusdecompression with instrumental fusionthe NORDSTEN degenerativespondylolisthesis trial (NORDSTEN-DS);study protocol for a randomized controlledtrial
Austevoll, Ivar Magne; Hermansen, Erland; Fagerland, Morten; Rekeland, Frode; Solberg, Tore; Storheim, Kjersti; Brox, Jens Ivar; Lønne, Greger; Indrekvam, Kari; Aaen, Jørn; Grundnes, Oliver; Hellum, Christian (BMC Musculoskeletal Disorders;20:07, Journal article; Peer reviewed, 2018-12-18)Background Fusion in addition to decompression has become the standard treatment for lumbar spinal stenosis with degenerative spondylolisthesis (DS). The evidence for performing fusion among these patients is conflicting ... -
Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis
Austevoll, Ivar Magne; Hermansen, Erland; Fagerland, Morten Wang; Storheim, Kjersti; Brox, Jens Ivar; Solberg, Tore; Rekeland, Frode; Franssen, Eric; Weber, Clemens; Brisby, Helena; Grundnes, Oliver; Algaard, Knut; Bøker, Tordis; Banitalebi, Hasan; Indrekvam, Kari; Hellum, Christian (New England Journal of Medicine;Vol. 385, No. 6, Peer reviewed; Journal article, 2021-08-05)Background: In patients with lumbar spinal stenosis and degenerative spondylolisthesis, it is uncertain whether decompression surgery alone is noninferior to decompression with instrumented fusion. Methods: We conducted ... -
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
Bråten, Lars Christian Haugli; Rolfsen, Mads Peder; Espeland, Ansgar; Wigemyr, Monica; Assmus, Jörg; Froholdt, Anne; Haugen, Anne Julsrud; Marchand, Gunn Hege; Kristoffersen, Per M; Lutro, Olav; Randen, Sigrun; Wilhelmsen, Maja; Winsvold, Bendik K S; Kadar, Thomas; Holmgard, Thor Einar; Vigeland, Maria Dehli; Vetti, Nils; Nygaard, Øystein Petter; Lie, Benedicte Alexandra; Hellum, Christian; Anke, Audny; Grotle, Margreth; Schistad, Ellina Iordanova; Skouen, Jan Sture; Grøvle, Lars; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (BMJ; 2019;367:l5654, Journal article; Peer reviewed, 2019-08-29)Objective: To assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes). Design: ... -
Evaluation of the EQ-5D-3L and 5L versions in low back pain patients
Garratt, Andrew; Furunes, Håvard; Hellum, Christian; Solberg, Tore; Brox, Jens Ivar; Storheim, Kjersti; Johnsen, Lars Gunnar (Health and Quality of Life Outcomes;19:155, Peer reviewed; Journal article, 2021-05-28)Background: The EuroQol EQ-5D is one of the most widely researched and applied patient-reported outcome measures worldwide. The original EQ-5D-3L and more recent EQ-5D-5L include three and five response categories respectively. ... -
Follow-up score, change score or percentage change score for determining clinical important outcome following surgery? An observational study from the Norwegian registry for Spine surgery evaluating patient reported outcome measures in lumbar spinal stenosis and lumbar degenerative spondylolisthesis
Austevoll, Ivar Magne; Gjestad, Rolf; Grotle, Margreth; Solberg, Tore; Brox, Jens Ivar; Hermansen, Erland; Rekeland, Frode; Indrekvam, Kari; Storheim, Kjersti; Hellum, Christian (BMC Musculoskeletal Disorders;20(31), Journal article; Peer reviewed, 2019)Assessment of outcomes for spinal surgeries is challenging, and an ideal measurement that reflects all aspects of importance for the patients does not exist. Oswestry Disability Index (ODI), EuroQol (EQ-5D) and Numeric ... -
Lumbar total disc replacement: predictors for long-term outcome
Furunes, Håvard; Hellum, Christian; Brox, Jens Ivar; Rossvoll, Ivar; Espeland, Ansgar; Berg, Linda; Brøgger, Helga Maria; Småstuen, Milada C; Storheim, Kjersti (Journal article; Peer reviewed, 2017)Purpose We aimed to identify patient characteristics associated with favourable long-term outcomes after lumbar total disc replacement (TDR). Methods We analysed a cohort of 82 patients with degenerative disc and ... -
The Norwegian degenerative spondylolisthesis and spinal stenosis (NORDSTEN) study: study overview, organization structure and study population
Indrekvam, Kari; Bånerud, Ingrid Fjeldheim; Hermansen, Erland; Austevoll, Ivar Magne; Rekeland, Frode Gurvin; Guddal, Maren Hjelle; Solberg, Tore; Brox, Jens Ivar; Hellum, Christian; Storheim, Kjersti (Peer reviewed; Journal article, 2023)Purpose To provide an overview of the The Norwegian Degenerative spondylolisthesis and spinal stenosis (NORDSTEN)- study and the organizational structure, and to evaluate the study population. Methods The NORDSTEN is a ... -
A novel MRI index for paraspinal muscle fatty infiltration: reliability and relation to pain and disability in lumbar spinal stenosis: results from a multicentre study
BANITALEBI, HASAN; Aaen, Jørn Ståle; Storheim, Kjersti; Negård, Anne; Myklebust, Tor Åge; Grotle, Margreth; Hellum, Christian; Espeland, Ansgar; Anvar, Masoud D; Indrekvam, Kari; Weber, Clemens; Brox, Jens Ivar; Brisby, Helena; Hermansen, Erland (European Radiology Experimental;6, Article number: 38 (2022), Peer reviewed; Journal article, 2022-07-20)Background: Fatty infiltration of the paraspinal muscles may play a role in pain and disability in lumbar spinal stenosis. We assessed the reliability and association with clinical symptoms of a method for assessing fatty ... -
Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes-subgroup analysis of a randomized trial
Kristoffersen, Per M; Bråten, Lars Christian Haugli; Vetti, Nils; Grøvle, Lars; Hellum, Christian; Storheim, Kjersti; Zwart, John-Anker; Assmus, Jörg; Espeland, Ansgar (European Radiology;, Journal article; Peer reviewed, 2020-11-27)Objective To evaluate potential MRI-defined effect modifiers of amoxicillin treatment in patients with chronic low back pain and type 1 or 2 Modic changes (MCs) at the level of a previous lumbar disc herniation (index ... -
Surgery in Degenerative Spondylolisthesis: Does fusion improve outcome in subgroups? A secondary analysis from a randomized trial (NORDSTEN trial)
Hellum, Christian; Rekeland, Frode Gurvin; Småstuen, Milada Cvancarova; Solberg, Tore; Hermansen, Erland; Storheim, Kjersti; Brox, Jens Ivar; Furunes, Håvard; Franssen, Eric; Weber, Clemens; Brisby, Helena; Grundnes, Oliver; Robert Hector Algaard, Knut; Bøker, Tordis; Banitalebi, Hasan; Indrekvam, Kari; Austevoll, Ivar Magne (Peer reviewed; Journal article, 2023)BACKGROUND CONTEXT: Patients with spinal stenosis and degenerative spondylolisthesis are treated surgically with decompression alone or decompression with fusion. However, there is debate regarding which subgroups of ...