• Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range 

      Andersen, Jorunn Marie; Herning, Hilde; Aschim, Elin L.; Hjelmesæth, Jøran; Mala, Tom; Hanevik, Hans Ivar; Bungum, Mona; Haugen, Trine B.; Witczak, Oliwia (PloS one;10(6), Journal article; Peer reviewed, 2015-06-12)
      There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard ...
    • Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome 

      Bucher-Johannessen, Cecilie; Page, Christian Magnus; Haugen, Trine B.; Wojewodzic, Marcin; Fosså, Sophie Dorothea; Grotmol, Tom; Haugnes, Hege Sagstuen; Rounge, Trine Ballestad (Clinical Epigenetics;11, Article number: 179 (2019), Journal article; Peer reviewed, 2019-12-03)
      Background: Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. In this epigenomewide ...
    • Disiplinfagenes plass i profesjonsutdanningene 

      Haugen, Trine B. (Peer reviewed; Chapter, 2011)
    • Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor 

      Litchfield, Kevin; Levy, Max; Orlando, Giulia; Loveday, Chey; Law, Philip J.; Migliorini, Gabriele; Holroyd, Amy; Broderick, Peter; Karlsson, Robert; Haugen, Trine B.; Kristiansen, Wenche; Nsengimana, Jérémie; Fenwick, Kerry; Assiotis, Ioannis; Kote-Jarai, Zsofia; Dunning, Alison M.; Muir, Kenneth; Peto, Julian; Eeles, Rosalind; Easton, Douglas F.; Dudakia, Darshna; Orr, Nick; Pashayan, Nora; Bishop, D. Timothy; Reid, Alison; Huddart, Robert A.; Shipley, Janet; Grotmol, Tom; Wiklund, Fredrik; Houlston, Richard S.; Turnbull, Clare (Nature Genetics;Volume 49, Issue 7, Journal article; Peer reviewed, 2017-06-12)
      Genome-wide association studies (GWAS) have transformed our understanding of testicular germ cell tumour (TGCT) susceptibility but much of the heritability remains unexplained. Here we report a new GWAS, a meta-analysis ...
    • Identification of Endogenous Controls for Use in miRNA Quantification in Human Cancer Cell Lines 

      Das, Mrinal Kumar; Andreassen, Rune; Haugen, Trine B.; Furu, Kari (Cancer Genomics & Proteomics;13(1), Journal article; Peer reviewed, 2016)
      Background: miRNAs play important roles in multiple biological processes, and deregulation has been linked to several human diseases, including cancer. Studying changes in miRNA expression in cancer development is commonly ...
    • Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours 

      Das, Mrinal Kumar; Furu, Kari; Evensen, Herman Sebastian Folkestad; Haugen, Øyvind Pernell; Haugen, Trine B. (Scientific Reports;Volume 8, Article number: 2462 (2018), Journal article; Peer reviewed, 2018-02-06)
      Testicular germ cell tumour (TGCT) is the most common cancer in young men in large parts of the world, but the aetiology is mainly unknown. Genome-wide association studies have so far identified about 50 susceptibility ...
    • Machine Learning-Based Analysis of Sperm Videos and Participant Data for Male Fertility Prediction 

      Hicks, Steven; Andersen, Jorunn Marie; Witczak, Oliwia; Lasantha Bandara Thambawita, Vajira; Halvorsen, Pål; Hammer, Hugo Lewi; Haugen, Trine B.; Riegler, Michael Alexander (Scientific Reports;9, Article number: 16770 (2019), Journal article; Peer reviewed, 2019-10-24)
      Methods for automatic analysis of clinical data are usually targeted towards a specific modality and do not make use of all relevant data available. In the field of male human reproduction, clinical and biological data are ...
    • Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor 

      Wang, Zhaoming; McGlynn, Katherine A.; Rajpert-De Meyts, Ewa; Bishop, D. Timothy; Chung, Charles C.; Dalgaard, Marlene D.; Greene, Mark H.; Gupta, Ramneek; Grotmol, Tom; Haugen, Trine B.; Karlsson, Robert; Litchfield, Kevin; Mitra, Nandita; Nielsen, Kasper; Pyle, Louise C.; Schwartz, Stephen M.; Thorsson, Vesteinn; Vardhanabhuti, Saran; Wiklund, Fredrik; Turnbull, Clare; Chanock, Stephen J.; Kanetsky, Peter A.; Nathanson, Katherine L. (Nature Genetics;Volume 49, Issue 7, Journal article; Peer reviewed, 2017-06-12)
      The international TEsticular CAncer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumors (TGCT; 3,558 cases and 13,970 controls) to identify novel susceptibility loci. ...
    • Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs 

      Rounge, Trine Ballestad; Furu, Kari; Skotheim, Rolf Inge; Haugen, Trine B.; Grotmol, Tom; Enerly, Espen (Journal article; Peer reviewed, 2015)
      Background Small non-coding RNAs play essential roles in gene regulation, however, the interplay between RNA groups, their expression levels and deregulations in tumorigenesis requires additional exploration. In particular, ...
    • Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage 

      Malm, Gunilla; Haugen, Trine B.; Rylander, Lars; Giwercman, Aleksander (Asian Journal of Andrology;Volume 19, Issue 1, Journal article; Peer reviewed, 2017-01)
      A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and ...
    • Serum RNA profiling in the 10-year period prior to diagnosis of testicular germ cell tumour 

      Burton, Joshua; Umu, Sinan Uğur; Langseth, Hilde; Grotmol, Tom; Grimsrud, Tom Kristian; Haugen, Trine B.; Rounge, Trine Ballestad (Frontiers in Oncology;volume 10, Peer reviewed; Journal article, 2020-10-28)
      Although testicular germ cell tumor (TGCT) overall is highly curable, patients may experience late effects after treatment. An increased understanding of the mechanisms behind the development of TGCT may pave the way for ...
    • Sædanalysen 

      Witczak, Oliwia; Evensen, Herman Sebastian Folkestad; Andersen, Jorunn Marie; Herning, Hilde; Haugen, Trine B. (Journal article; Peer reviewed, 2017)
      Bakgrunn: Sædanalysen er et viktig verktøy i utredningen av ufrivillig barnløshet. Standard sædanalyse inkluderer spermiekonsentrasjon, totalt antall spermier, spermiemotilitet og spermiemorfologi. Analysen er basert på ...
    • VISEM: A Multimodal Video Dataset of Human Spermatozoa 

      Haugen, Trine B.; Hicks, Steven; Andersen, Jorunn Marie; Witczak, Oliwia; Hammer, Hugo Lewi; Borgli, Rune Johan; Halvorsen, Pål; Riegler, Michael (ACM MMSys conference series;, Chapter; Peer reviewed, 2019)
      Real multimedia datasets that contain more than just images or text are rare. Even more so are open multimedia datasets in medicine. Often, clinically related datasets only consist of image or videos. In this paper, we ...