Blar i ODA Open Digital Archive på forfatter "Christiansen, Irene Kraus"
-
Changes in intrahost genetic diversity according to lesion severity in longitudinal HPV16 samples
Costanzi, Jean-Marc; Stosic, Milan; Løvestad, Alexander; Ambur, Ole Herman; Rounge, Trine Ballestad; Christiansen, Irene Kraus (Peer reviewed; Journal article, 2024)Human papillomavirus type 16 (HPV16) is the most common cause of cervical cancer, but most infections are transient with lesions not progressing to cancer. There is a lack of specific biomarkers for early cancer risk ... -
"HPV chromosomal integration as a biomarker for cancer progression" Validation and characterization of integration sites in HPV31, 33 and 45 positive cervical samples
Repesa, Adina (Master thesis, 2021-05)Background: Human papillomavirus (HPV) is associated with 4.5% of all human cancers worldwide including cervical cancer. Cytological and/or HPV primary screening is used to uncover cancer precursors. Still, better clinical ... -
HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization
Meisal, Roger; Rounge, Trine Ballestad; Christiansen, Irene Kraus; Eieland, Alexander Kirkeby; Worren, Merete Molton; Molden, Tor; Kommedal, Øyvind; Hovig, Eivind; Leegaard, Truls Michael; Ambur, Ole Herman (Journal article; Peer reviewed, 2017)Sensitive and specific genotyping of human papillomaviruses (HPVs) is important for population-based surveillance of carcinogenic HPV types and for monitoring vaccine effectiveness. Here we compare HPV genotyping by Next ... -
HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples
Lagström, Sonja; Løvstad, Alexander H; Umu, Sinan Uğur; Ambur, Ole Herman; Nygård, Mari; Rounge, Trine Ballestad; Christiansen, Irene Kraus (Tumour Virus Research;Volume 12, December 2021, 200221, Peer reviewed; Journal article, 2021-07-14)Human papillomavirus (HPV) 16 and 18 are the most predominant types in cervical cancer. Only a small fraction of HPV infections progress to cancer, indicating that additional factors and genomic events contribute to the ... -
HPV16 whole genome minority variants in persistent infections from young Dutch women
Lagström, Sonja; van der Weele, Pascal; Rounge, Trine Ballestad; Christiansen, Irene Kraus; King, Audrey; Ambur, Ole Herman (Journal of Clinical Virology;Volume 119, October 2019, Journal article; Peer reviewed, 2019-08-09)Background: Chronic infections by one of the oncogenic human papillomaviruses (HPVs) are responsible for near 5% of the global cancer burden and HPV16 is the type most often found in cancers. HPV genomes displayunexpected ... -
Intra-host sequence variability in human papillomavirus
Mandishora, Racheal Shamiso Dube; Gjøtterud, Kristina Stormo; Lagström, Sonja; Stray-Pedersen, Babill; Duri, Kerina; Chin'ombe, Nyasha; Nygård, Mari; Christiansen, Irene Kraus; Ambur, Ole Herman; Chirenje, Mike Zvavahera; Rounge, Trine Ballestad (Papillomavirus Research. The Journal of HPV and other Small DNA Tumor Viruses;Volume 5, June 2018, Journal article; Peer reviewed, 2018-04-30)Human papillomaviruses (HPVs) co-evolve slowly with the human host and each HPV genotype displays epithelial tropisms. We assessed the evolution of intra HPV genotype variants within samples, and their association to ... -
Substantial Decline in Prevalence of Vaccine-Type and Nonvaccine-Type Human Papillomavirus (HPV) in Vaccinated and Unvaccinated Girls 5 Years After Implementing HPV Vaccine in Norway
Feiring, Berit; Laake, Ida; Christiansen, Irene Kraus; Hansen, Mona Lindsethmo; Stålcrantz, Jeanette; Ambur, Ole Herman; Magnus, Per; Jonassen, Christine M; Trogstad, Lill (Journal of Infectious Diseases;, Journal article; Peer reviewed, 2018-07-16)Background: In 2009, quadrivalent human papillomavirus (HPV) vaccine was introduced in a school-based single-cohort program targeting 12-year-old girls in Norway. We estimated the impact of the Norwegian HPV immunization ... -
TaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration
Lagström, Sonja; Umu, Sinan Uğur; Lepistö, Maija; Ellonen, Pekka; Meisal, Roger; Christiansen, Irene Kraus; Ambur, Ole Herman; Rounge, Trine Ballestad (Scientific Reports;9, Article number: 524 (2019), Journal article; Peer reviewed, 2018-11-26)HPV genomic variability and chromosomal integration are important in the HPV-induced carcinogenic process. To uncover these genomic events in an HPV infection, we have developed an innovative and cost-effective sequencing ... -
The Valgent4 protocol: Robust analytical and clinical validation of 11 HPV assays with genotyping on cervical samples collected in SurePath medium
Bonde, Jesper; Ejegod, Ditte Møller; Cuschieri, Kate; Dillner, Joakim; Heideman, Daniëlle A. M.; Quint, Wim; Ribas, Miguel Angel pavon; Padalko, Elizaveta; Christiansen, Irene Kraus; Xu, Lan; Arbyn, Marc (Journal of Clinical Virology;108, Journal article; Peer reviewed, 2018-09-14)Background The VALidation of HPV GENoyping Tests (VALGENT) is an international initiative designed to validate HPV assays with genotyping capability. The VALGENT4 protocol differs from previous VALGENT installments as the ...