Browsing ODA Open Digital Archive by Author "Andreassen, Rune"
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Characterization of differentially expressed miRNAs and their predicted target transcripts associated with smoltification and seawater adaptation in Atlantic salmon
Shwe, Alice (OsloMet Avhandling;2023 nr 39, Doctoral thesis, 2023)Smoltification, or parr-smolt transformation, is a complex pre-adaptive process of behavioral, developmental, biochemical, and physiological changes that transforms an Atlantic salmon parr living in freshwater (FW) into a ... -
Characterization of Differentially Expressed miRNAs and Their Predicted Target Transcripts during Smoltification and Adaptation to Seawater in Head Kidney of Atlantic Salmon
Shwe, Alice; Østbye, Tone-Kari K; Krasnov, Aleksei; Ramberg, Sigmund; Andreassen, Rune (Genes;Volume 11, Issue 9, Journal article; Peer reviewed, 2020-09-08)Smoltification and early seawater phase are critical developmental periods with physiological and biochemical changes in Atlantic salmon that facilitates survival in saltwater. MicroRNAs (miRNAs) are known to have important ... -
Characterization of miRNAs in cultured atlantic salmon head kidney monocyte-like and macrophage-like cells
Smith, Nicole; Woldemariam, Nardos Tesfaye; Rise, Matthew L.; Andreassen, Rune (International Journal of Molecular Sciences;Volume 21 / Issue 11, Journal article; Peer reviewed, 2020-06-02)Macrophages are among the first cells to respond to infection and disease. While microRNAs (miRNAs) are involved in the process of monocyte-to-macrophage differentiation in mammals, less is known in teleost fish. Here, ... -
Characterization of miRNAs in Embryonic, Larval, and Adult Lumpfish Provides a Reference miRNAome for Cyclopterus lumpus
Chakraborty, Setu; Woldemariam, Nardos Tesfaye; Visnovska, Tina; Rise, Matthew L.; Santander, Javier; Andreassen, Rune (Biology;Volume 11 / Issue 1, Peer reviewed; Journal article, 2022-01-13)MicroRNAs (miRNAs) are endogenous small RNA molecules involved in the post-transcriptional regulation of protein expression by binding to the mRNA of target genes. They are key regulators in teleost development, maintenance ... -
Characterization of the impact of dietary immunostimulant CpG on the expression of mRNA biomarkers involved in the immune responses in Atlantic salmon (Salmo salar)
Xue, Xi; Eslamloo, Khalil; Andreassen, Rune; Rise, Matthew L. (Peer reviewed; Journal article, 2024)Infectious diseases have significantly impacted Atlantic salmon aquaculture worldwide. Modulating fish immunity with immunostimulant-containing functional feeds could be an effective strategy in mitigating disease problems. ... -
A de novo Full-Length mRNA Transcriptome Generated From Hybrid-Corrected PacBio Long-Reads Improves the Transcript Annotation and Identifies Thousands of Novel Splice Variants in Atlantic Salmon
Ramberg, Sigmund; Bjørn, Høyheim; tone-kari, knutsdatter østbye; Andreassen, Rune (Frontiers in Genetics;April 2021 | Volume 12 | Article 656334, Peer reviewed; Journal article, 2021-04-27)Atlantic salmon (Salmo salar) is a major species produced in world aquaculture and an important vertebrate model organism for studying the process of rediploidization following whole genome duplication events (Ss4R, 80 ... -
Dietary Immunostimulant CpG Modulates MicroRNA Biomarkers Associated with Immune Responses in Atlantic Salmon (Salmo salar)
Xue, Xi; Woldemariam, Nardos Tesfaye; Rise, Matthew L.; Andreassen, Rune (Cells;Volume 8, Issue 12, Journal article; Peer reviewed, 2019-12-05)MicroRNAs (miRNAs) are key regulators in fish immune responses. However, no study has previously characterized the impact of polyriboinosinic polyribocytidylic acid (pIC) and formalin-killed typical Aeromonas salmonicida ... -
Differential Expression of miRNAs and Their Predicted Target Genes Indicates That Gene Expression in Atlantic Salmon Gill Is Post-Transcriptionally Regulated by miRNAs in the Parr-Smolt Transformation and Adaptation to Sea Water
Shwe, Alice; Krasnov, Aleksei; Visnovska, Tina; Ramberg, Sigmund; Tone-Kari, Østbye; Andreassen, Rune (International Journal of Molecular Sciences;Volume 23 / Issue 15, Peer reviewed; Journal article, 2022-08-08)Smoltification (parr-smolt transformation) is a complex developmental process consisting of developmental changes that lead to remodeling of the Atlantic salmon gill. Here, the expression changes of miRNAs and mRNAs were ... -
The Discovery and Characterization of Conserved and Novel miRNAs in the Different Developmental Stages and Organs of Pikeperch (Sander lucioperca)
Verleih, Marieke; Visnovska, Tina; Nguinkal, Julien; Rebl, Alexander; Goldammer, Tom; Andreassen, Rune (Peer reviewed; Journal article, 2024)Micro RNAs (miRNAs) are short non-coding RNAs that act as post-transcriptional gene expression regulators. Genes regulated in vertebrates include those affecting growth and development or stress and immune response. ... -
Discovery and characterization of miRNA genes in atlantic salmon (Salmo salar) by use of a deep sequencing approach
Andreassen, Rune; Worren, Merete Molton; Høyheim, Bjørn (BMC genomics;14 (1), Journal article; Peer reviewed, 2013-07-12)Background MicroRNAs (miRNAs) are an abundant class of endogenous small RNA molecules that downregulate gene expression at the posttranscriptional level. They play important roles in multiple biological processes by ... -
Discovery of microRNAs associated with the antiviral immune response of Atlantic cod macrophages
Eslamloo, Khalil; Inkpen, Sabrina; Rise, Matthew L.; Andreassen, Rune (Journal article; Peer reviewed, 2018)MicroRNAs (miRNAs) are known to play important immunoregulatory roles in teleosts, although miRNAs involved in the antiviral immune response of Atlantic cod (Gadus morhua) were previously uncharacterised. Using deep ... -
Discovery of miRNAs and Their Corresponding miRNA Genes in Atlantic Cod(Gadus morhua): Use of Stable miRNAs as Reference Genes Reveals Subgroups of miRNAs That Are Highly Expressed in Particular Organs
Andreassen, Rune; Worren, Merete Molton (Peer reviewed; Journal article; Journal article, 2016-04-29)Background Atlantic cod (Gadus morhua) is among the economically most important species in the northern Atlantic Ocean and a model species for studying development of the immune system in vertebrates. MicroRNAs (miRNAs) ... -
A DNA profiling system for conservation management of Kamchatka brown bear (Ursus arctos piscator); population data and system performance from 16 autosomal STRs
Andreassen, Rune; Hansen, Berit; Klutsch, Cornelya; Fløystad, Ida; Kling, Daniel; Eiken, Hans Geir; Hagen, Snorre (Forensic Science International: Animals and Environments;, Peer reviewed; Journal article, 2024)Despite the high density of brown bears (Ursus arctos piscator) on the Kamchatka peninsula their genetic variation has not been studied by STR analysis. Our aim was, therefore, to provide population data from the Kamchatka ... -
Expanding the miRNA Repertoire in Atlantic Salmon; Discovery of IsomiRs and miRNAs Highly Expressed in Different Tissues and Developmental Stages
Woldemariam, Nardos Tesfaye; Høyheim, Bjørn; Andreassen, Rune (Cells;Volume 8, Issue 1, Journal article; Peer reviewed, 2019-01-11)MicroRNAs (miRNAs) are important post-transcriptional gene expression regulators. Here, 448 different miRNA genes, including 17 novel miRNAs, encoding for 589 mature Atlantic salmon miRNAs were identified after sequencing ... -
Expression Analysis in Atlantic Salmon Liver Reveals miRNAs Associated with Smoltification and Seawater Adaptation
Shwe, Alice; Krasnov, Aleksei; Visnovska, Martina; Ramberg, Sigmund; Tone-Kari, Østbye; Andreassen, Rune (Biology (Basel);Volume 11 / Issue 5, Peer reviewed; Journal article, 2022-04-30)Smoltification is a developmental process that preadapts Atlantic salmon for a life in seawater. Suboptimal smoltification and poor timing of transfer to seawater is associated with increased mortality. MicroRNAs (miRNAs) ... -
Identification of differentially expressed Atlantic salmon miRNAs responding to salmonid alphavirus (SAV) infection
Andreassen, Rune; Nardos, Woldemariam; Ine, Egeland; Oleg, Agafanov; Hilde, Sindre; Bjørn, Høyheim (Journal article; Peer reviewed, 2017)Background MicroRNAs (miRNAs) control multiple biological processes including the innate immune responses by negative post-transcriptional regulation of gene expression. As there were no studies on the role(s) of miRNAs ... -
Identification of Endogenous Controls for Use in miRNA Quantification in Human Cancer Cell Lines
Das, Mrinal Kumar; Andreassen, Rune; Haugen, Trine B.; Furu, Kari (Cancer Genomics & Proteomics;13(1), Journal article; Peer reviewed, 2016)Background: miRNAs play important roles in multiple biological processes, and deregulation has been linked to several human diseases, including cancer. Studying changes in miRNA expression in cancer development is commonly ... -
miRNAs associated with immune response in teleost fish
Andreassen, Rune; Høyheim, Bjørn (Journal article; Peer reviewed, 2017)MicroRNAs (miRNAs) have been identified as important post transcriptional regulators of gene expression. In higher vertebrates, a subset of miRNAs has been identified as important regulators of a number of key genes in ... -
miRNAs Predicted to Regulate Host Anti-viral Gene Pathways in IPNV-Challenged Atlantic Salmon Fry Are Affected by Viral Load, and Associated With the Major IPN Resistance QTL Genotypes in Late Infection
Woldemariam, Nardos Tesfaye; Agafonov, Aleksander; Sindre, Hilde; Høyheim, Bjørn; Andreassen, Rune (Frontiers in Immunology;September 2020 | Volume 11 | Article 2113, Journal article; Peer reviewed, 2020-09-11)Infectious pancreatic necrosis virus (IPNV) infection has been a major problem in salmonid aquaculture. Marker-assisted selection of individuals with resistant genotype at the major IPN quantitative trait locus (IPN-QTL) ... -
Modulation of hepatic miRNA expression in Atlantic salmon (Salmo salar) by family background and dietary fatty acid composition
Østbye, Tone-Kari K; Woldemariam, Nardos Tesfaye; Lundberg, Camilla S.; Berge, Gerd Marit; Ruyter, Bente; Andreassen, Rune (Journal of Fish Biology;, Journal article; Peer reviewed, 2020-12-17)This study finds significant differences in hepatic fatty acid composition between four groups of Atlantic salmon (Salmo salar) consisting of offspring from families selected for high and low capacities to express the delta ...