Blar i ODA Open Digital Archive på forfatter "Ambur, Ole Herman"
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The alginate polymer OligoG alters susceptibility of biofilm-embedded non-typeable Haemophilus influenzae to ampicillin and ciprofloxacin
Marienborg, Kaja; Ambur, Ole Herman; Økstad, Ole Andreas; Skaare, Dagfinn (Peer reviewed; Journal article, 2023)Objectives Treatment of respiratory infections with non-typeable Haemophilus influenzae (NTHi) in COPD patients is complicated by biofilm formation, protecting the bacteria against the hosts’ immune response and antibiotics. ... -
Changes in intrahost genetic diversity according to lesion severity in longitudinal HPV16 samples
Costanzi, Jean-Marc; Stosic, Milan; Løvestad, Alexander; Ambur, Ole Herman; Rounge, Trine Ballestad; Christiansen, Irene Kraus (Peer reviewed; Journal article, 2024)Human papillomavirus type 16 (HPV16) is the most common cause of cervical cancer, but most infections are transient with lesions not progressing to cancer. There is a lack of specific biomarkers for early cancer risk ... -
The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants
Kværner, Ane Sørlie; Birkeland, Einar Elvbakken; Bucher-Johannessen, Cecilie; Vinberg, Elina; Nordby, Jan Inge; Kangas, Harri; Bemanian, Vahid; Ellonen, Pekka; Botteri, Edoardo; Natvig, Erik; Rognes, Torbjørn; Hovig, Eivind; Lyle, Robert; Ambur, Ole Herman; de Vos, Willem M.; Bultman, Scott J; Hjartåker, Anette; Landberg, Rikard; Song, Mingyang; Blix, Hege Salvesen; Ursin, Giske; Randel, Kristin Ranheim; de Lange, Thomas; Hoff, Geir; Holme, Øyvind; Berstad, Paula; Rounge, Trine Ballestad (BMC Cancer;21, Article number: 930 (2021), Peer reviewed; Journal article, 2021-08-18)Background: Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness as primary ... -
A genomic view of experimental intra- and interspecies transformation of a rifampicin resistance allele into Neisseria meningitidis
Alfsnes, Kristian; Frye, Stephan Alfons; Eriksson, JE; Tonjum, Tone; Eldholm, Vegard; Brynildsrud, Ola Brønstad; Bohlin, Jon; Harrison, OB; Hood, D; Maiden, Martin C.J.; Ambur, Ole Herman (Microbial Genomics;, Journal article; Peer reviewed, 2018-09-25)The spread of antibiotic resistance within and between different bacterial populations is a major health problem on a global scale. The identification of genetic transformation in genomic data from Neisseria meningitidis, ... -
HPV chromosomal integration as a biomarker for cancer progression
Repesa, Adina (Master thesis, 2021)Background: Human papillomavirus (HPV) is associated with 4,5% of all human cancers worldwide including cervical cancer. Cytological and/or HPV primary screening is used to uncover cancer precursors. Still, better clinical ... -
"HPV chromosomal integration as a biomarker for cancer progression" Validation and characterization of integration sites in HPV31, 33 and 45 positive cervical samples
Repesa, Adina (Master thesis, 2021-05)Background: Human papillomavirus (HPV) is associated with 4.5% of all human cancers worldwide including cervical cancer. Cytological and/or HPV primary screening is used to uncover cancer precursors. Still, better clinical ... -
HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization
Meisal, Roger; Rounge, Trine Ballestad; Christiansen, Irene Kraus; Eieland, Alexander Kirkeby; Worren, Merete Molton; Molden, Tor; Kommedal, Øyvind; Hovig, Eivind; Leegaard, Truls Michael; Ambur, Ole Herman (Journal article; Peer reviewed, 2017)Sensitive and specific genotyping of human papillomaviruses (HPVs) is important for population-based surveillance of carcinogenic HPV types and for monitoring vaccine effectiveness. Here we compare HPV genotyping by Next ... -
HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples
Lagström, Sonja; Løvstad, Alexander H; Umu, Sinan Uğur; Ambur, Ole Herman; Nygård, Mari; Rounge, Trine Ballestad; Christiansen, Irene Kraus (Tumour Virus Research;Volume 12, December 2021, 200221, Peer reviewed; Journal article, 2021-07-14)Human papillomavirus (HPV) 16 and 18 are the most predominant types in cervical cancer. Only a small fraction of HPV infections progress to cancer, indicating that additional factors and genomic events contribute to the ... -
HPV16 whole genome minority variants in persistent infections from young Dutch women
Lagström, Sonja; van der Weele, Pascal; Rounge, Trine Ballestad; Christiansen, Irene Kraus; King, Audrey; Ambur, Ole Herman (Journal of Clinical Virology;Volume 119, October 2019, Journal article; Peer reviewed, 2019-08-09)Background: Chronic infections by one of the oncogenic human papillomaviruses (HPVs) are responsible for near 5% of the global cancer burden and HPV16 is the type most often found in cancers. HPV genomes displayunexpected ... -
Intra-host sequence variability in human papillomavirus
Mandishora, Racheal Shamiso Dube; Gjøtterud, Kristina Stormo; Lagström, Sonja; Stray-Pedersen, Babill; Duri, Kerina; Chin'ombe, Nyasha; Nygård, Mari; Christiansen, Irene Kraus; Ambur, Ole Herman; Chirenje, Mike Zvavahera; Rounge, Trine Ballestad (Papillomavirus Research. The Journal of HPV and other Small DNA Tumor Viruses;Volume 5, June 2018, Journal article; Peer reviewed, 2018-04-30)Human papillomaviruses (HPVs) co-evolve slowly with the human host and each HPV genotype displays epithelial tropisms. We assessed the evolution of intra HPV genotype variants within samples, and their association to ... -
Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping
Mandishora, Racheal S. Dube; Rounge, Trine Ballestad; Fitzpatrick, Megan; Christiansen, Hanne Irene Kraus; Ambur, Ole Herman; Lagström, Sonja; Stray-Pedersen, Babill; Tommasino, Massimo; Palefsky, Joel; Chirenje, Zvavahera M. (PLOS ONE;16 (4): e0250426, Peer reviewed; Journal article, 2021-04-26)Background & aim: Women with HIV/HPV coinfection and cervical lesions are at increased risk of developing HPV related anal cancer. Self-collection of anal swabs may facilitate HPV molecular testing in anal cancer screening, ... -
Substantial Decline in Prevalence of Vaccine-Type and Nonvaccine-Type Human Papillomavirus (HPV) in Vaccinated and Unvaccinated Girls 5 Years After Implementing HPV Vaccine in Norway
Feiring, Berit; Laake, Ida; Christiansen, Irene Kraus; Hansen, Mona Lindsethmo; Stålcrantz, Jeanette; Ambur, Ole Herman; Magnus, Per; Jonassen, Christine M; Trogstad, Lill (Journal of Infectious Diseases;, Journal article; Peer reviewed, 2018-07-16)Background: In 2009, quadrivalent human papillomavirus (HPV) vaccine was introduced in a school-based single-cohort program targeting 12-year-old girls in Norway. We estimated the impact of the Norwegian HPV immunization ... -
TaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration
Lagström, Sonja; Umu, Sinan Uğur; Lepistö, Maija; Ellonen, Pekka; Meisal, Roger; Christiansen, Irene Kraus; Ambur, Ole Herman; Rounge, Trine Ballestad (Scientific Reports;9, Article number: 524 (2019), Journal article; Peer reviewed, 2018-11-26)HPV genomic variability and chromosomal integration are important in the HPV-induced carcinogenic process. To uncover these genomic events in an HPV infection, we have developed an innovative and cost-effective sequencing ... -
Viral genomics by next-generation sequencing – investigating intra-host genomic events in human papillomavirus and improving intra-hospital outbreak investigations of SARS-CoV-2
Løvestad, Alexander Hesselberg (OsloMet Avhandling;2023 nr 2, Doctoral thesis, 2023)Human Papillomaviruses (HPVs) are one of the oldest human pathogens and the most common sexually transmitted pathogenic infection worldwide. Most HPV infections are cleared by the immune system, but some infections persist ...