Blar i ODA Open Digital Archive på forfatter "Akslen, Lars A"
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Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer
Kruger, Kristi; Wik, Elisabeth; Knutsvik, Gøril; Nalwoga, Hawa; Klingen, Tor Audun; Arnes, Jarle; Chen, Ying; Mannelqvist, Monica; Dimitrakopoulou, Konstantina; Stefansson, Ingunn; Birkeland, Even; Aas, Turid; Tobin, Nicholas P; Jonassen, Inge; Bergh, Jonas; Foulkes, William D; Akslen, Lars A (Scientific Reports;7(1), Journal article; Peer reviewed, 2017-04-24)We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent ... -
Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer
Aziz, Sura Mohammed; Wik, Elisabeth; Knutsvik, Gøril; Klingen, Tor Audun; Chen, Ying; Davidsen, Benedicte; Aas, Hans; Aas, Turid; Akslen, Lars A (PloS one;12(2), Journal article; Peer reviewed, 2017-02-15)Presence of lymph node (LN) metastasis is a strong prognostic factor in breast cancer, whereas the importance of extra-nodal extension and other nodal tumor features have not yet been fully recognized. Here, we examined ... -
Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users
Ellingjord-Dale, Merete; Lee, Eunjung; Couto, Elisabeth; Ozhand, Ali; Qureshi, Samera A; Hofvind, Solveig; van Den Berg, David J; Akslen, Lars A; Grotmol, Tom; Ursin, Giske (Breast Cancer Research;14 (R135), Journal article; Peer reviewed, 2012-10-27)Introduction Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by ... -
Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma
Pilskog, Martin; Beisland, Christian; Akslen, Lars A; Bostad, Leif; Haug, Åse; Heinrich, Daniel; Hjelle, Karin Margrethe; Straume, Oddbjørn (BMC Urology;17(1), Journal article; Peer reviewed, 2017-08-31)Background Sunitinib has become mainstay first line treatment for patients with metastatic renal clear cell carcinoma (mRCC). Still, useful predictive markers of response are lacking and urgently needed for clinical ... -
Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer
Klingen, Tor Audun; Chen, Ying; Aas, Hans; Wik, Elisabeth; Akslen, Lars A (Human Pathology;69, Journal article; Peer reviewed, 2017-11)Tumor-associated macrophages (TAM) resemble M2 macrophages, promote tumor invasion and show strong expression of CD163 in breast cancer. We here investigated the association between CD163-positive macrophages and vascular ...