• Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 

      Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard (Journal article; Peer reviewed, 2017)
      Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like ...
    • The genetic architecture of human brainstem structures and their involvement in common brain disorders 

      Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K.; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A.; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar August; Jonassen, Rune; Jönsson, Erik G.; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; O’ Connell, Kevin S.; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin; de Quervain, Dominique; Reif, Andreas; Rokicki, Jaroslav; Van Rooij, Daan; Shadrin, Alexey A.; Schmidt, André; Schwarz, Emanuel; Selbæk, Geir; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar M.; Tsolaki, Magda; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Kaufmann, Tobias (Nature Communications;11:4016, Journal article; Peer reviewed, 2020-08-11)
      Brainstem regions support vital bodily functions, yet their genetic architectures and invol- vement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 ...
    • A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis 

      Madireddy, Lohith; Patsopoulos, Nikolaos A.; Cotsapas, Chris; Bos, Steffan Daniel; Beecham, Ashley; McCauley, Jacob; Kim, Kicheol; Jia, Xiaoming; Santaniello, Adam; Caillier, Stacy J.; Andlauer, Till F.M.; Barcellos, Lisa F.; Berge, Tone; Bernardinelli, Luisa; Martinelli-Boneschi, Filippo; Booth, David R.; Briggs, Farren; Celius, Elisabeth Gulowsen; Comabella, Manuel; Comi, Giancarlo; Cree, Bruce A.C.; D'Alfonso, Sandra; Dedham, Katrina; Duquette, Pierre; Efthimios, Dardiotis; Esposito, Federica; Fontaine, Bertrand; Gasperi, Christiane; Goris, An; Dubois, Bénédicte; Gourraud, Pierre-Antoine; Hadjigeorgiou, Georgios; Haines, Jonathan; Hawkins, Clive; Hemmer, Bernhard; Hintzen, Rogier; Horakova, Dana; Isobe, Noriko; Kalra, Seema; Kira, Jun-ichi; Khalil, Michael; Kockum, Ingrid; Lill, Christina M.; Lincoln, Matthew R; Luessi, Felix; Martin, Roland; Oturai, Annette; Palotie, Aarno; Pericak-Vance, Margaret A.; Henry, Roland; Saarela, Janna; Ivinson, Adrian; Olsson, Tomas; Taylor, Bruce V.; Stewart, Graeme J.; Harbo, Hanne Flinstad; Compston, Alastair; Hauser, Stephen L.; Hafler, David A.; Zipp, Frauke; De Jager, Philip; Sawcer, Stephen; Oksenberg, Jorge R.; Baranzini, Sergio E. (Nature Communications;10, Article number: 2236 (2019), Journal article; Peer reviewed, 2019-05-20)
      Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...
    • A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. 

      Madireddy, L; Patsopoulos, NA; Cotsapas, C; Bos, Steffan Daniel; Beecham, Ashley; McCauley, J; Kim, K; Jia, X; Santaniello, A; Caillier, SJ; Andlauer, TFM; Barcellos, Lisa; Berge, Tone; Bernardinelli, L; Martinelli-Boneschi, F; Booth, D; Briggs, Farren; Celius, Elisabeth Gulowsen; Comabella, M; Comi, G; Cree, BAC; D'Alfonso, S; Dedham, K; Duquette, P.; Dardiotis, E; Esposito, F; Gasperi, Christiane; Goris, A; Dubois, B; Gourraud, PA; Hadjigeorgiou, GM; Haines, J; Hawkins, C; Hemmer, B; Hintzen, R; Horakova, D; Isobe, N; Kalra, S; Kira, Jun-ichi; Khalil, M; Kockum, I; Lill, CM; Lincoln, Michelle; Luessi, F; Martin, R; Oturai, A; Palotie, A; Pericak-Vance, MA; Henry, R; Saarela, J; Ivinson, Adrian; Olsson, Thomas; Taylor, Bruce; Stewart, GJ; Harbo, Hanne Flinstad; Compston, A; Hauser, SL; Hafler, DA; Zipp, F; De Jager, P; Sawcer, S; Oksenberg, JR; Baranzini, SE (Nature Communications;10, Article number: 2236 (2019), Journal article; Peer reviewed, 2019-03-26)
      Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...