Browsing ODA Open Digital Archive by Journals "Basic & Clinical Pharmacology & Toxicology"

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Effect of CYP2D6 genotype on duloxetine serum concentration

Hole, Kristine; Gangsø, Sofie; Jensstuen, Åse Tonette; Ormøy, Hanne Holte; Paulsen, Maren; Molden, Espen; Haslemo, Tore (Peer reviewed; Journal article, 2023)

Duloxetine is metabolized by cytochrome P450 (CYP)1A2 and CYP2D6. The aim of this study was to investigate the effect of the CYP2D6 genotype on duloxetine serum concentration adjusting for age and sex. Patients were included ...
Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes

Lao, Yvonne Elisabeth; Molden, Espen; Kringen, Marianne K.; Annexstad, Ellen Johanne; Sæverud, Håvard Andreassen; Jacobsen, Dag; Hovda, Knut Erik (Basic & Clinical Pharmacology & Toxicology;Volume 127, Issue 1, July 2020, Journal article; Peer reviewed, 2020-01-24)

Paracetamol has a good safety profile, but pharmacogenetic differences in drug-metabolizing enzymes may have an impact on its risk of hepatotoxicity. We present a case of fatal acute liver failure (ALF) after therapeutic ...