Browsing ODA Open Digital Archive by Author "O'Connell, Kevin Sean"

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    • Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo 

      Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kausberg, Marianne; Mæland, Sondre; Tveito, Marit; O'Connell, Kevin Sean; Molden, Espen; Kringen, Marianne K. (Current drug metabolism;Volume 23, Issue 1, Peer reviewed; Journal article, 2022)
      Background: Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact of various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on the exposure and metabolism of CLZ in vivo is ...

    • Mismatch negativity and polygenic risk scores for schizophrenia and bipolar disorder 

      Pentz, Atle Bråthen; O'Connell, Kevin Sean; van Jole, Oda; Timpe, Clara Marie Fides; Slapø, Nora Berz; Melle, Ingrid; Lagerberg, Trine Vik; Steen, Nils Eiel; Westlye, Lars Tjelta; Haukvik, Unn Kristin Hansen; Moberget, Torgeir; Jönsson, Erik Gunnar; Andreassen, Ole A.; Elvsåshagen, Torbjørn (Peer reviewed; Journal article, 2024)
      Objective: Auditory mismatch negativity (MMN) impairment is a candidate endophenotype in psychotic disorders, yet the genetic underpinnings remain to be clarified. Here, we examined the relationships between auditory MMN ...