Blar i HV - Institutt for rehabiliteringsvitenskap og helseteknologi på forfatter "Zwart, John Anker Henrik"

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    • Anterior surgical treatment for cervical degenerative radiculopathy: A prediction model for non-success 

      Mjåset, Christer; Solberg, Tore; Zwart, John Anker Henrik; Småstuen, Milada Cvancarova; Kolstad, Frode; Grotle, Margreth (Peer reviewed; Journal article, 2022)
      Purpose By using data from the Norwegian Registry for Spine Surgery, we wanted to develop and validate prediction models for non-success in patients operated with anterior surgical techniques for cervical degenerative ...

    • Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood 

      Baumann-Larsen, Monica; Storheim, Kjersti; Stangeland, Helle; Zwart, John Anker Henrik; Wentzel-Larsen, Tore; Skurtveit, Svetlana Ondrasova; Dyb, Grete Anita; Stensland, Synne (Journal article; Peer reviewed, 2023)
      Opioid and nonopioid analgesics are commonly prescribed to young people to alleviate pain. Even short-term prescriptions incr the risk of persistent use and future misuse of potent analgesics, such as opioids. Childhood ...

    • Clinical improvement after surgery for degenerative cervical myelopathy; A comparison of Patient-Reported Outcome Measures during 12-month follow-up 

      Mjåset, Christer; Zwart, John Anker Henrik; Kolstad, Frode; Solberg, Tore; Grotle, Margreth (PLOS ONE;17 (3): e0264954, Peer reviewed; Journal article, 2022-03-08)
      Object: Although many patients report clinical improvement after surgery due to degenerative cervical myelopathy, the aim of intervention is to stop progression of spinal cord dysfunction. We wanted to provide estimates ...

    • COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study 

      Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette; Gundersen, Trude; Zayats, Tetyana; Winsvold, Bendik Kristoffer Slagsvold; Karen, Rosendahl; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Fors, Egil Andreas; Kristoffersen, Espen Saxhaug; Heuch, Ingrid; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Nielsen, Jonas B.; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars G; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Lie, Marie U.; Stensland, Synne; Zhou, Wei (Peer reviewed; Journal article, 2023)
      Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults ...

    • Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement 

      Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Kristoffersen, Per Martin; Vetti, Nils; Wigemyr, Monica; Bråten, Lars Christian Haugli; Gjefsen, Elisabeth; Schistad, Ellina Iordanova; Haugen, Anne Julsrud; Johanessen, Anne Froholdt; Skouen, Jan Sture; Zwart, John Anker Henrik; Storheim, Kjersti; Pedersen, Linda Margareth; Lie, Benedicte Alexandra (Scientific Reports;12, Article number: 215 (2022), Peer reviewed; Journal article, 2022-01-07)
      Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifable by MRI ...

    • Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study) 

      Bråten, Lars Christian Haugli; Gjefsen, Elisabeth; Gervin, Kristina; Pripp, Are Hugo; Skouen, Jan Sture; Schistad, Elina Iordanova; Pedersen, Linda Margareth; Wigemyr, Monica; Selmer, Kaja Kristine; Dalsbotten Aass, Hans Christian; Goll, Guro Løvik; Brox, Jens Ivar; Espeland, Ansgar; Grøvle, Lars; Zwart, John Anker Henrik; Storheim, Kjersti (Peer reviewed; Journal article, 2023)
      Objective: Randomized trials testing the effect of antibiotics for chronic low back pain (LBP) with vertebral bone marrow changes on MRI (Modic changes) report inconsistent results. A proposed explanation is subgroups ...

    • Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome 

      Dhariwal, Achal; Bråten, Lars Christian Haugli; Sturød, Kjersti; Salvadori Da Silva, Gabriela; Bargheet, Ahmed; Åmdal, Heidi Aarø; Junges, Roger; Berild, Dag; Zwart, John Anker Henrik; Storheim, Kjersti; Petersen, Fernanda Cristina (Peer reviewed; Journal article, 2023)
      The collateral impact of antibiotics on the microbiome has attained increasing attention. However, the ecological consequences of long-term antibiotic exposure on the gut microbiome, including anti- biotic resistance, ...

    • Exposure to traumatic events and use of over-the-counter analgesics in adolescents: cross-sectional findings from the Young-HUNT study 

      Baumann-Larsen, Monica; Dyb, Grete Anita; Wentzel-Larsen, Tore; Zwart, John Anker Henrik; Storheim, Kjersti; Stensland, Synne Øien Blixt (Peer reviewed; Journal article, 2023)
      Objective Frequent and increasing use of over-the- counter analgesics (OTCA) among adolescents is a public health concern. Prior research indicates that adolescents exposed to traumatic events may be at increased risk of ...

    • Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity 

      Bakker, Mark K.; Kanning, Jos P.; Abraham, Gad; Martinsen, Amy; Winsvold, Bendik Kristoffer Slagsvold; Zwart, John Anker Henrik; Bourcier, Romain; Sawada, Tomonobu; Koido, Masaru; Kamatani, Yoichiro; Morel, Sandrine; Amouyel, Philippe; Debette, Stéphanie; Bijlenga, Philippe; Berrandou, Takiy; Ganesh, Santhi K.; Bouatia-Naji, Nabila; Jones, Gregory; Bown, Matthew; Rinkel, Gabriel J.E.; Veldink, Jan H.; Ruigrok, Ynte M.; Aamodt, Anne Hege; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Sandset, Else Charlotte; Kristoffersen, Espen Saxhaug; Ellekjær, Hanne; Heuch, Ingrid; Nielsen, Jonas Bille; Hagen, Knut; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Holmen, Oddgeir Lingaas; Børte, Sigrid; Schmidt, Helena; Stubhaug, Audun; Nielsen, Christopher Sivert; Johnsen, Marianne Bakke; Sandvei, Marie Søfteland (Peer reviewed; Journal article, 2023)
      BACKGROUND: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to ...

    • Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions 

      Khoury, Samar; Parisien, Marc; Thompson, Scott J.; Vachon-Presseau, Etienne; Roy, Mathieu; Mitchell, Amy; Winsvold, Bendik K S; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J.; Fors, Egil Andreas; Heuch, Ingrid; Nielsen, Jonas Bille; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Kania, Artur; Mogil, Jeffrey S.; Diatchenko, Luda (Brain;Volume 145, Issue 3, Peer reviewed; Journal article, 2021-11-11)
      Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ...

    • Killing pain? A prospective population-based study on trauma exposure in childhood as predictor for frequent use of over-the-counter analgesics in young adulthood. The HUNT study 

      Baumann-Larsen, Monica; Zwart, John Anker Henrik; Dyb, Grete Anita; Wentzel-Larsen, Tore; Stangeland, Helle; Storheim, Kjersti; Stensland, Synne Øien Blixt (Peer reviewed; Journal article, 2023)
      Frequent and increasing use of over-the-counter analgesics (OTCA) is a public health concern. Pain conditions and psychological distress are related to frequent OTCA use, and as exposure to potentially traumatic events (PTE) ...

    • Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes 

      Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Zucknick, Manuela; Wigemyr, Monica; Bråten, Lars Christian Haugli; Gjefsen, Elisabeth; Zwart, John Anker Henrik; Storheim, Kjersti; Pedersen, Linda Margareth; Selmer, Kaja Kristine; Lie, Benedicte Alexandra; Gervin, Kristina (Peer reviewed; Journal article, 2023)
      Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We con- ducted longitudinal transcriptome ...

    • Longitudinal changes of serum cytokines in patients with chronic low back pain and Modic changes 

      Gjefsen, Elisabeth; Gervin, Kristina; Bråten, Lars Christian Haugli; Goll, Guro Løvik; Aass, Hans Christian; Schistad, Elina Iordanova; Wigemyr, Monica; Pedersen, Linda Margareth; Skouen, Jan Sture; Vigeland, Maria Dehli; Selmer, Kaja Kristine; Storheim, Kjersti; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2023)
      Objectives: To explore serum cytokine levels over time in patients with chronic low back pain (cLBP) and Modic changes (MCs), difference in change between treatment groups in the Antibiotics in Modic Changes (AIM) study ...

    • Longitudinal Relationship Between Reduced Modic Change Edema and Disability and Pain in Patients With Chronic Low Back Pain 

      Espeland, Ansgar; Kristoffersen, Per Martin; Bråten, Lars Christian Haugli; Grøvle, Lars; Grotle, Margreth; Haugen, Anne Julsrud; Rolfsen, Mads Peder; Hellum, Christian; Zwart, John Anker Henrik; Storheim, Kjersti; Assmus, Jörg; Vetti, Nils (Peer reviewed; Journal article, 2023)
      Study Design. Secondary analyses of a randomized trial [Antibiotics In Modic changes (MCs) study]. Objective. To assess whether or not reduced MC edema over time is related to reduced disability and pain in patients ...

    • Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC 

      Lie, Marie; Pedersen, Linda Margareth; Heuch, Ingrid; Winsvold, Bendik K S; Gjerstad, Johannes; Hasvik, Eivind Olay; Nygaard, Øystein Petter; Grotle, Margreth; Matre, Dagfinn; Zwart, John Anker Henrik; Nilsen, Kristian Bernhard (Frontiers in Genetics;January 2022 | Volume 12 | Article 757632, Peer reviewed; Journal article, 2022-01-24)
      In a recently published genome-wide association study (GWAS) chronic back pain was associated with three loci; SOX5, CCDC26/GSDMC and DCC. This GWAS was based on a heterogeneous sample of back pain disorders, and it is ...

    • Musculoskeletal pain is not clearly associated with the risk of anterior cruciate ligament reconstruction in adolescents 

      Strømme, Sofie Hammernes; Guddal, Maren Hjelle; Fenstad, Anne Marie; Visnes, Håvard; Zwart, John Anker Henrik; Storheim, Kjersti; Johnsen, Marianne Bakke (Peer reviewed; Journal article, 2023)
      Objectives The purpose of this study was to investigate whether self-reported musculoskeletal pain (MSP) was associated with a future anterior cruciate ligament reconstruction (ACLR). Methods In this population-based ...

    • Musculoskeletal pain is not clearly associated with the risk of anterior cruciate ligament reconstruction in adolescents 

      Strømme, Sofie Hammernes; Guddal, Maren Hjelle; Fenstad, Anne Marie; Visnes, Håvard; Zwart, John Anker Henrik; Storheim, Kjersti; Johnsen, Marianne Bakke (Peer reviewed; Journal article, 2023)
      Objectives The purpose of this study was to investigate whether self-reported musculoskeletal pain (MSP) was associated with a future anterior cruciate ligament reconstruction (ACLR). Methods In this population-based ...

    • Musculoskeletal pain is not clearly associated with the risk of anterior cruciate ligament reconstruction in adolescents 

      Strømme, Sofie Hammernes; Guddal, Maren Hjelle; Fenstad, Anne Marie; Visnes, Håvard; Zwart, John Anker Henrik; Storheim, Kjersti; Johnsen, Marianne Bakke (Journal article; Peer reviewed, 2023)
      Background Greater Trochanteric Pain Syndrome (GTPS) is a common chronic musculoskeletal condition that may affect physical function, quality of life and sleep. The Victorian Institute of Sport Assessment-Gluteal questionnaire ...